About: Localization of the STAT3 binding site in the MDR1 enhanceosom     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • The work evidenced that STAT3-induced over-expression of MDR1 is dependent on area assigned *824, so we can conclude that in this area is localized the crucial STAT3 binding site. Area *824 contains direct repeat with a three-nucleotide spacer and a three direct repeats with four-nucleotide spacer. Previous studies have shown that pregnane X receptor and constitutive androstane receptor, members of the nuclear receptor superfamily, as well as thyroid hormone receptors, mediate the up-regulation of MDR1 through this response region located -7.9 to -7.8 kb upstream of the MDR1 using an epithelial cell line LS174T or Caco2 (Burk et al., 2005; Geick et al., 2001; Kurose et al. 2008). This illustrates the general importance of this enhancer region upstream of MDR1 gene.
  • The work evidenced that STAT3-induced over-expression of MDR1 is dependent on area assigned *824, so we can conclude that in this area is localized the crucial STAT3 binding site. Area *824 contains direct repeat with a three-nucleotide spacer and a three direct repeats with four-nucleotide spacer. Previous studies have shown that pregnane X receptor and constitutive androstane receptor, members of the nuclear receptor superfamily, as well as thyroid hormone receptors, mediate the up-regulation of MDR1 through this response region located -7.9 to -7.8 kb upstream of the MDR1 using an epithelial cell line LS174T or Caco2 (Burk et al., 2005; Geick et al., 2001; Kurose et al. 2008). This illustrates the general importance of this enhancer region upstream of MDR1 gene. (en)
Title
  • Localization of the STAT3 binding site in the MDR1 enhanceosom
  • Localization of the STAT3 binding site in the MDR1 enhanceosom (en)
skos:prefLabel
  • Localization of the STAT3 binding site in the MDR1 enhanceosom
  • Localization of the STAT3 binding site in the MDR1 enhanceosom (en)
skos:notation
  • RIV/00216224:14310/11:00055973!RIV12-MSM-14310___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 209811
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/11:00055973
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • STAT3; MDR1; enhanceosom (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [24565A1EF629]
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Gudernová, Iva
  • Kotasová, Hana
  • Pacherník, Jiří
  • Procházková, Jiřina
  • Šrámková, Zuzana
  • Tmejová, Kateřina
http://localhost/t...ganizacniJednotka
  • 14310
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software