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  • The work evidenced that STAT3-induced over-expression of MDR1 is dependent on area assigned *824, so we can conclude that in this area is localized the crucial STAT3 binding site. Area *824 contains direct repeat with a three-nucleotide spacer and a three direct repeats with four-nucleotide spacer. Previous studies have shown that pregnane X receptor and constitutive androstane receptor, members of the nuclear receptor superfamily, as well as thyroid hormone receptors, mediate the up-regulation of MDR1 through this response region located -7.9 to -7.8 kb upstream of the MDR1 using an epithelial cell line LS174T or Caco2 (Burk et al., 2005; Geick et al., 2001; Kurose et al. 2008). This illustrates the general importance of this enhancer region upstream of MDR1 gene.
  • The work evidenced that STAT3-induced over-expression of MDR1 is dependent on area assigned *824, so we can conclude that in this area is localized the crucial STAT3 binding site. Area *824 contains direct repeat with a three-nucleotide spacer and a three direct repeats with four-nucleotide spacer. Previous studies have shown that pregnane X receptor and constitutive androstane receptor, members of the nuclear receptor superfamily, as well as thyroid hormone receptors, mediate the up-regulation of MDR1 through this response region located -7.9 to -7.8 kb upstream of the MDR1 using an epithelial cell line LS174T or Caco2 (Burk et al., 2005; Geick et al., 2001; Kurose et al. 2008). This illustrates the general importance of this enhancer region upstream of MDR1 gene. (en)
Title
  • Localization of the STAT3 binding site in the MDR1 enhanceosom
  • Localization of the STAT3 binding site in the MDR1 enhanceosom (en)
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  • Localization of the STAT3 binding site in the MDR1 enhanceosom
  • Localization of the STAT3 binding site in the MDR1 enhanceosom (en)
skos:notation
  • RIV/00216224:14310/11:00055973!RIV12-MSM-14310___
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  • 209811
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  • RIV/00216224:14310/11:00055973
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  • STAT3; MDR1; enhanceosom (en)
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  • [24565A1EF629]
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  • Gudernová, Iva
  • Kotasová, Hana
  • Pacherník, Jiří
  • Procházková, Jiřina
  • Šrámková, Zuzana
  • Tmejová, Kateřina
http://localhost/t...ganizacniJednotka
  • 14310
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