About: Clotting factors and eicosanoids protect against nematode infections

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Entomopathogenic nematodes (EPNs) of the genera Heterorhabditis are obligate and lethal insect parasites. In recent years they have been used increasingly as biological control agents. Infective juveniles occur free living in the soil and are capable of seeking out hosts and penetrate them through the cuticle or natural orifices. EPNs are symbiotically associated with bacteria of the genera Photorhabdus. The bacterial symbionts are essential to kill the host (within 24-48 hours) and digest host tissues. Drosophila larvae are more resistant to nematode infection than Galleria mellonella, but both can be used as natural infection model. The tripartite model (Drosophila, nematodes, bacteria) was recently established and used to show an immune function for transglutaminase, a conserved clotting factor. In this study we used different Drosophila mutants or RNAi lines with defects in clotting or other branches of the immune system. Entomopathogenic nematodes (EPNs) of the genera Heterorhabditis are obligate and lethal insect parasites. In recent years they have been used increasingly as biological control agents. Infective juveniles occur free living in the soil and are capable of seeking out hosts and penetrate them through the cuticle or natural orifices. EPNs are symbiotically associated with bacteria of the genera Photorhabdus. The bacterial symbionts are essential to kill the host (within 24-48 hours) and digest host tissues. Drosophila larvae are more resistant to nematode infection than Galleria mellonella, but both can be used as natural infection model. The tripartite model (Drosophila, nematodes, bacteria) was recently established and used to show an immune function for transglutaminase, a conserved clotting factor. In this study we used different Drosophila mutants or RNAi lines with defects in clotting or other branches of the immune system. (en)
Title	Clotting factors and eicosanoids protect against nematode infections Clotting factors and eicosanoids protect against nematode infections (en)
skos:prefLabel	Clotting factors and eicosanoids protect against nematode infections Clotting factors and eicosanoids protect against nematode infections (en)
skos:notation	RIV/00216224:14310/10:00048742!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GP206/09/P470)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hyršl, Pavel
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	250982
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00048742
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Drosophila; Heterorhabditis; immunity; clotting; eicosanoids (en)
http://linked.open.../riv/klicoveSlovo	eicosanoids Drosophila immunity Heterorhabditis clotting
http://linked.open...ontrolniKodProRIV	[1AB9F8854872]
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The influence of the eicosanoid biosynthesis inhibitors to immunity of the wax moth Galleria mellonella
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Dobeš, Pavel Hyršl, Pavel Theopold, Ulrich Wang, Zhi
http://localhost/t...ganizacniJednotka	14310

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