About: NMR determination of pKa values of indoloquinoline alkaloids

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Malaria is one of the most serious global health problems. Isolating new therapeutic agents with potential antimalarial activity from natural sources or preparing such agents either semisynthetically or synthetically is one strategy for solving the problem of resistance constantly evolving to the drugs currently in use. For alkaloids, the acid-base dissociation constant, pKa, is an important characteristic, thought to be associated with biological activity. In this contribution, pKa values for several indoloquinoline alkaloids were determined by using 1H NMR spectroscopy in a mixture of solvents. The data were recalculated for water solutions using the correction factors reported previously. The structural dependence of the pKa values for cryptolepine and its isomers neocryptolepine, isocryptolepine and isoneocryptolepine as well as some substituted neocryptolepine derivatives is discussed. Malaria is one of the most serious global health problems. Isolating new therapeutic agents with potential antimalarial activity from natural sources or preparing such agents either semisynthetically or synthetically is one strategy for solving the problem of resistance constantly evolving to the drugs currently in use. For alkaloids, the acid-base dissociation constant, pKa, is an important characteristic, thought to be associated with biological activity. In this contribution, pKa values for several indoloquinoline alkaloids were determined by using 1H NMR spectroscopy in a mixture of solvents. The data were recalculated for water solutions using the correction factors reported previously. The structural dependence of the pKa values for cryptolepine and its isomers neocryptolepine, isocryptolepine and isoneocryptolepine as well as some substituted neocryptolepine derivatives is discussed. (en)
Title	NMR determination of pKa values of indoloquinoline alkaloids NMR determination of pKa values of indoloquinoline alkaloids (en)
skos:prefLabel	NMR determination of pKa values of indoloquinoline alkaloids NMR determination of pKa values of indoloquinoline alkaloids (en)
skos:notation	RIV/00216224:14310/09:00036368!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06030), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Grycová, Lenka Marek, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	329610
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00036368
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	1H NMR; chemical shift; cryptolepine; isocryptolepine; neocryptolepine; isoneocryptolepine; malaria; pH; determination of pKa (en)
http://linked.open.../riv/klicoveSlovo	cryptolepine pH 1H NMR malaria chemical shift determination of pKa isocryptolepine isoneocryptolepine neocryptolepine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D1E42577B74B]
http://linked.open...i/riv/nazevZdroje	Magnetic Resonance in Chemistry
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Marek, Radek Grycová, Lenka Dommisse, Roger Pieters, Luc
http://linked.open...ain/vavai/riv/wos	000271123300010
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	0749-1581
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	NMR determination of pKa values of indoloquinoline alkaloids NMR determination of pKa values of indoloquinoline alkaloids NMR determination of pKa values of indoloquinoline alkaloids NMR determination of pKa values of indoloquinoline alkaloids

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