About: Procathepsin D mitogenic effect on breast cancer cells is mediated by the NFkB activation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Procathepsin D (pCD) is overexpressed and secreted by several types of tumors including breast cancer. pCD affects multiple stages of tumor progression including proliferation, angiogenesis and apoptosis. We have previously shown that mitogenic effect of pCD on cancer cells is mediated via its propeptide part (AP). However, the mechanism of pCD action on breast cancer cells is not known. In this study we demostrated an increased expression of NFkB luciferase reporter gene, translocation of p65 into cell nucleus, and phosphorylation of IkB in AP-treated MCF-7 breast cancer cells. Moreover, we confirmed that NFkB activity is essential for pro-mitogenic effect of pCD on MCF-7 cells using dominant negative IkB stable transfectants and pharmacological NFkB inhibitors. These results suggest that pharmacological inhibitors of NFkB may be useful for treatment of pCD-secreting tumors. Procathepsin D (pCD) is overexpressed and secreted by several types of tumors including breast cancer. pCD affects multiple stages of tumor progression including proliferation, angiogenesis and apoptosis. We have previously shown that mitogenic effect of pCD on cancer cells is mediated via its propeptide part (AP). However, the mechanism of pCD action on breast cancer cells is not known. In this study we demostrated an increased expression of NFkB luciferase reporter gene, translocation of p65 into cell nucleus, and phosphorylation of IkB in AP-treated MCF-7 breast cancer cells. Moreover, we confirmed that NFkB activity is essential for pro-mitogenic effect of pCD on MCF-7 cells using dominant negative IkB stable transfectants and pharmacological NFkB inhibitors. These results suggest that pharmacological inhibitors of NFkB may be useful for treatment of pCD-secreting tumors. (en)
Title	Procathepsin D mitogenic effect on breast cancer cells is mediated by the NFkB activation Procathepsin D mitogenic effect on breast cancer cells is mediated by the NFkB activation (en)
skos:prefLabel	Procathepsin D mitogenic effect on breast cancer cells is mediated by the NFkB activation Procathepsin D mitogenic effect on breast cancer cells is mediated by the NFkB activation (en)
skos:notation	RIV/00216224:14310/09:00028841!RIV11-AV0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GD204/08/H054), P(IAA501630801), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Beneš, Petr Šmarda, Jan Knopfová, Lucia Trčka, Filip Ondroušková, Eva
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	336671
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00028841
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	procathepsin D; breast cancer; NFKB; proliferation (en)
http://linked.open.../riv/klicoveSlovo	breast cancer proliferation NFKB procathepsin D
http://linked.open...ontrolniKodProRIV	[EC593EABEA0E]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of the cell proliferation and differentiation Mechanism of procathepsin D effect on breast cancer cells
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Beneš, Petr Knopfová, Lucia Šmarda, Jan Trčka, Filip Ondroušková, Eva Větvička, Václav Větvičková, Jana
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
http://localhost/t...ganizacniJednotka	14310

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