About: Limits of Accuracy of RNA Dynamics Studied by Model Free Analysis of C-13 Relaxation     Goto   Sponge   NotDistinct   Permalink

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  • The model free analysis of the relaxation data is one of the possible approaches to the investigation of the internal dynamics via NMR. However, the validity of the model-free approach for C-13 relaxation of nucleic acids has not been tested sufficiently. Especially, the properties of the chemical shielding tensor may not always meet the assumptions on which the model-free approach is based. The goal of this work was to find the conditions under which the model free analysis of the C-13 relaxation rates in nucleic acid bases is applicable with an acceptable accuracy. We have studied the effect for axially symmetric molecules with the ratio of the diffusion coefficients parallel and perpendicular to the axis of the molecule ranging from 2.4 to 8.2, corresponding to DNA duplexes with 12 to 30 base pairs. The results show that the studies of the relaxation behavior at 800 MHz of carbon C6 in pyrimidines are inaccurate for all studied molecules.
  • The model free analysis of the relaxation data is one of the possible approaches to the investigation of the internal dynamics via NMR. However, the validity of the model-free approach for C-13 relaxation of nucleic acids has not been tested sufficiently. Especially, the properties of the chemical shielding tensor may not always meet the assumptions on which the model-free approach is based. The goal of this work was to find the conditions under which the model free analysis of the C-13 relaxation rates in nucleic acid bases is applicable with an acceptable accuracy. We have studied the effect for axially symmetric molecules with the ratio of the diffusion coefficients parallel and perpendicular to the axis of the molecule ranging from 2.4 to 8.2, corresponding to DNA duplexes with 12 to 30 base pairs. The results show that the studies of the relaxation behavior at 800 MHz of carbon C6 in pyrimidines are inaccurate for all studied molecules. (en)
Title
  • Limits of Accuracy of RNA Dynamics Studied by Model Free Analysis of C-13 Relaxation
  • Limits of Accuracy of RNA Dynamics Studied by Model Free Analysis of C-13 Relaxation (en)
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  • Limits of Accuracy of RNA Dynamics Studied by Model Free Analysis of C-13 Relaxation
  • Limits of Accuracy of RNA Dynamics Studied by Model Free Analysis of C-13 Relaxation (en)
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  • RIV/00216224:14310/07:00023225!RIV10-MSM-14310___
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  • P(LC06030), Z(MSM0021622413)
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  • 431093
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  • RIV/00216224:14310/07:00023225
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  • dynamics; NMR spectroscopy; nucleic acid; relaxation; chemical shift anisotropy (en)
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  • [6C3511B38C6A]
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  • Valtice
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  • Brno
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  • 22nd NMR Valtice
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  • Kadeřávek, Pavel
  • Fiala, Radovan
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  • Masarykova univerzita
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  • 978-80-86441-38-2
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  • 14310
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