About: Molecular dissection of Rad52 mediator activity

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.embo.org/yip/yip_meeting07.html
Description	DNA strand break repair by HR is mediated by genes of the RAD52 epistasis group. Rad52 protein plays central role in this process. It binds and anneals complementary ssDNA, self-associate to form multimeric rings, interacts with Rad51, and promotes nucleation of Rad51 onto ssDNA. Here, we show that Rad52 competes with Srs2 anti-recombinase in mediating Rad51-catalyzed strand exchange reaction through common interaction site on Rad51. The molecular mechanism of Rad52 function in homologous recombination together with the role of postranslational modification (SUMO-ylation) is discussed. DNA strand break repair by HR is mediated by genes of the RAD52 epistasis group. Rad52 protein plays central role in this process. It binds and anneals complementary ssDNA, self-associate to form multimeric rings, interacts with Rad51, and promotes nucleation of Rad51 onto ssDNA. Here, we show that Rad52 competes with Srs2 anti-recombinase in mediating Rad51-catalyzed strand exchange reaction through common interaction site on Rad51. The molecular mechanism of Rad52 function in homologous recombination together with the role of postranslational modification (SUMO-ylation) is discussed. (en)
Title	Molecular dissection of Rad52 mediator activity Molecular dissection of Rad52 mediator activity (en)
skos:prefLabel	Molecular dissection of Rad52 mediator activity Molecular dissection of Rad52 mediator activity (en)
skos:notation	RIV/00216224:14310/07:00022863!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06030), P(ME 888), Z(MSM0021622413)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Krejčí, Lumír
http://linked.open.../riv/druhVysledku	A(V) - Audiovizuální tvorba se vzdáleným přístupem
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	434842
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00022863
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	recombination; repair; cancer; Rad52; BRCA2 (en)
http://linked.open.../riv/klicoveSlovo	BRCA2 cancer recombination repair Rad52
http://linked.open...i/riv/kodPristupu	V
http://linked.open...ontrolniKodProRIV	[6F66AC60CF04]
http://linked.open...i/riv/mistoVydani	Heidelberg
http://linked.open...telVyzkumneZpravy	EMBO
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20888
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Krejčí, Lumír
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
http://localhost/t...ganizacniJednotka	14310

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