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Description
  • Termodynamika a struktura lektinu Pseudomonas aeruginosa a jejich interakce s lidskými glykokonjugáty (cs)
  • Carbohydrate-mediated recognition plays an important role in the ability of pathogenic bacteria to adhere to the surface of the host cell in the first step of their invasion and infectivity. Together with carbohydrate receptors located on pili and flagellum, Pseudomonas aeruginosa also expresses soluble galactose- and fucose-binding lectins (PA-IL and PA-IIL). Complexes between both lectins and their monosaccharide ligands have been characterized by a variety of methods, including enzyme-amplification (ELLA), titration microcalorimetry, x-ray crystallography and molecular modeling. PA-IIL displays an affinity for fucose in micromolar range, unusually high for monosaccharide binding. These characteristics are correlated to the remarkable presence of two calcium ions in the binding site of the protein. When searching for ligands of biological interest, PA-IIL lectin displays highest affinity for lewis a, a trisaccharide located on epithelial cell glycoconjugates of CF patients, and human milk oligosacch
  • Carbohydrate-mediated recognition plays an important role in the ability of pathogenic bacteria to adhere to the surface of the host cell in the first step of their invasion and infectivity. Together with carbohydrate receptors located on pili and flagellum, Pseudomonas aeruginosa also expresses soluble galactose- and fucose-binding lectins (PA-IL and PA-IIL). Complexes between both lectins and their monosaccharide ligands have been characterized by a variety of methods, including enzyme-amplification (ELLA), titration microcalorimetry, x-ray crystallography and molecular modeling. PA-IIL displays an affinity for fucose in micromolar range, unusually high for monosaccharide binding. These characteristics are correlated to the remarkable presence of two calcium ions in the binding site of the protein. When searching for ligands of biological interest, PA-IIL lectin displays highest affinity for lewis a, a trisaccharide located on epithelial cell glycoconjugates of CF patients, and human milk oligosacch (en)
Title
  • Thermodynamic and structures of Pseudomonas aeruginosa lectins and their interaction with complex human glycoconjugates
  • Termodynamika a struktura lektinu Pseudomonas aeruginosa a jejich interakce s lidskými glykokonjugáty (cs)
  • Thermodynamic and structures of Pseudomonas aeruginosa lectins and their interaction with complex human glycoconjugates (en)
skos:prefLabel
  • Thermodynamic and structures of Pseudomonas aeruginosa lectins and their interaction with complex human glycoconjugates
  • Termodynamika a struktura lektinu Pseudomonas aeruginosa a jejich interakce s lidskými glykokonjugáty (cs)
  • Thermodynamic and structures of Pseudomonas aeruginosa lectins and their interaction with complex human glycoconjugates (en)
skos:notation
  • RIV/00216224:14310/05:00021389!RIV08-MSM-14310___
http://linked.open.../vavai/riv/strany
  • 278-278
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika
  • 4/5/6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 546709
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/05:00021389
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Pseudomonas aeruginosa; lectin; X-ray; cysticka fibrosa (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [A00D3197ABE7]
http://linked.open...i/riv/nazevZdroje
  • Glycoconjugate Journal
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 22
http://linked.open...iv/tvurceVysledku
  • Imberty, Anne
  • Pokorná, Martina
  • Wimmerová, Michaela
  • Mitchell, Edward P.
  • Sabin, Charles
  • Roy, Rene
http://linked.open...n/vavai/riv/zamer
issn
  • 0282-0080
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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