About: Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In order to investigate the versatility of proteome of leukemic cells undergoing terminal differentiation, we performed two-dimensional electrophoresis of proteins extracted from BM2 monoblasts induced differentiation inducers TPA and TSA for various time periods and compared it with two-dimensional electrophoretogram of untreated control cells. Similar analyses were performed with BM2RAR cells upon induction with retinoic acid. Some of the spots of differentially expressed proteins were digested with trypsin and identified by MALDI-TOF mass spectrometry as heat shock protein 70, protein-glutamine glutamyltransferase 4, prostaglandin-D-synthase, EMS1, nucleobindin 2 precursor (DNA-binding protein NEFA), actin, ARP2/3 protein complex subunit 3 and chaperonin Hsp60. Biological significance of versatility of these proteins in differentiating BM2 cells is currently investigated. In order to investigate the versatility of proteome of leukemic cells undergoing terminal differentiation, we performed two-dimensional electrophoresis of proteins extracted from BM2 monoblasts induced differentiation inducers TPA and TSA for various time periods and compared it with two-dimensional electrophoretogram of untreated control cells. Similar analyses were performed with BM2RAR cells upon induction with retinoic acid. Some of the spots of differentially expressed proteins were digested with trypsin and identified by MALDI-TOF mass spectrometry as heat shock protein 70, protein-glutamine glutamyltransferase 4, prostaglandin-D-synthase, EMS1, nucleobindin 2 precursor (DNA-binding protein NEFA), actin, ARP2/3 protein complex subunit 3 and chaperonin Hsp60. Biological significance of versatility of these proteins in differentiating BM2 cells is currently investigated. (en)
Title	Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts (en)
skos:prefLabel	Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts (en)
skos:notation	RIV/00216224:14310/05:00012382!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/03/1055), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Černá, Karolína Váňa, Petr Zdráhal, Zbyněk Šmarda, Jan Ondroušková, Eva Konečná, Hana
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	548732
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/05:00012382
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	proteom; v-Myb; diferenciace; hmotnostní spektrometrie; dvourozměrná elektroforéza (en)
http://linked.open.../riv/klicoveSlovo	dvourozměrná elektroforéza hmotnostní spektrometrie proteom v-Myb diferenciace
http://linked.open...ontrolniKodProRIV	[358EB779F0D4]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	Sborník příspěvků IX. pracovního setkání biochemiků a molekulárních biologů
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of molecular mechanisms causing v-Myb suppression using proteomics-based approach
http://linked.open...UplatneniVysledku	2005
http://linked.open...iv/tvurceVysledku	Konečná, Hana Zdráhal, Zbyněk Černá, Karolína Šmarda, Jan Ondroušková, Eva Váňa, Petr
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open.../riv/zahajeniAkce	2005-02-09 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Masarykova univerzita v Brně
https://schema.org/isbn	80-210-3635-4
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts

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