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  • MD simulace na LgtC (cs)
  • glycosyltransferases catalyze the transfer of glycosyl moieties from a donor sugar to an acceptor. In most cases, the donor is a nucleoside phosphosugar and the acceptor a hydroxyl group of another sugar, a lipid, or another component of glycoconjugates. The catalytic mechanism of the glycosyltransferases, however, still remains a mystery. The glycosyltransferases are classified as either retaining or inverting, depending on the stereochemical outcome of the reaction catalyzed. The galactosyltransferase LgtC from Neisseria meningitidis is a retaning glycosyltransferase catalyzing a key step in the biosynthesis of lipooligosaccharide structure by transferring alpha-D-galactose from UDP-galactose to a terminal lactose. The comprehension of the catalytic mechanism is an essential precondition to be able to design an effective inhibitor of this enzyme, and to find an effective drug against the bacterial pathogen in this way. We report here the first molecular dynamics simulations of LgtC in water environm
  • glycosyltransferases catalyze the transfer of glycosyl moieties from a donor sugar to an acceptor. In most cases, the donor is a nucleoside phosphosugar and the acceptor a hydroxyl group of another sugar, a lipid, or another component of glycoconjugates. The catalytic mechanism of the glycosyltransferases, however, still remains a mystery. The glycosyltransferases are classified as either retaining or inverting, depending on the stereochemical outcome of the reaction catalyzed. The galactosyltransferase LgtC from Neisseria meningitidis is a retaning glycosyltransferase catalyzing a key step in the biosynthesis of lipooligosaccharide structure by transferring alpha-D-galactose from UDP-galactose to a terminal lactose. The comprehension of the catalytic mechanism is an essential precondition to be able to design an effective inhibitor of this enzyme, and to find an effective drug against the bacterial pathogen in this way. We report here the first molecular dynamics simulations of LgtC in water environm (en)
Title
  • MD simulace na LgtC (cs)
  • Molecular Dynamics Simulations on Glycosyltrasferase LgtC
  • Molecular Dynamics Simulations on Glycosyltrasferase LgtC (en)
skos:prefLabel
  • MD simulace na LgtC (cs)
  • Molecular Dynamics Simulations on Glycosyltrasferase LgtC
  • Molecular Dynamics Simulations on Glycosyltrasferase LgtC (en)
skos:notation
  • RIV/00216224:14310/04:00010190!RIV08-MSM-14310___
http://linked.open.../vavai/riv/strany
  • 52-52
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LN00A016)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 574374
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/04:00010190
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • molecular dynamics; glycosyltransferase; LgtC (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [2E9A5D9FACAC]
http://linked.open...v/mistoKonaniAkce
  • Praha
http://linked.open...i/riv/mistoVydani
  • Praha
http://linked.open...i/riv/nazevZdroje
  • Materials Structure in Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Imberty, Anne
  • Koča, Jaroslav
  • Šnajdrová, Lenka
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
number of pages
http://purl.org/ne...btex#hasPublisher
  • Czech and Slovak Crystallographic Association
http://localhost/t...ganizacniJednotka
  • 14310
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