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| Description
| - Biomolecular center is designed as an expert laboratory for studiyng the structure and properties of biologically relevant molecules and biopolymers, with main emphasis on proteins and nucleic acid fragments. On the horizontal level the Center will havea strong background in methods for studiing the biomolecules on the atomic level using NMR spectroscopy, molecular modeling and X-ray crystallography with appropriate support of biochemistry and molecular biology. The Center will be able to studythe biomolecular systems in the vertical direction starting with the atomic structure, through their in vitro properties to their function in living cells. From the very beginning, the Center will activelly participate in Ph.D programs (already now 14PhD. students). In the final stage, 25 core scientist will be employed in the Center with a significant support from postdoctoral fellows and PhD. students (2/3 of all coworkers). The group is involved in a large number of international projects. (en)
- Biomolekulární centrum je koncipováno jako expertní pracoviště v oblasti studia struktury a vlastností biologicky významných molekul a polymerů, především proteinů a fragmentů nukleových kyselin. V horizontální rovině je cílem vybudování centras vynikajícím zázemím v metodách studia biomolekul na atomární úrovni s využitím NMR spektroskopie, počítačového modelování a rentgenové krystalografie spolu s patřičnou podporou v oblasti biochemie a molekulární biologie. Centrum bude schopné vertikálněstudovat biomolekulární systémy počínaje jejich atomární strukturou, přes in vitro biochemické projevy, až po jejich funkční projevy v živém organismu. Centrum ve finální podobě počítá s 25 kmenovými pracovníky. Centrum bude mít od počátku dobřepropracovanou vazbu na doktorské studium (14 PGS studentů). Na činnosti Centra se budou aktivně podílet postdoktorální stážisté a doktorandi (v závěrečné fázi 2/3 všech pracovníků). Kolektiv je již dnes aktivně zapojen do široké mezinárodní spolupráce.
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| Title
| - BIOMOLECULAR CENTER (en)
- BIOMOLEKULÁRNÍ CENTRUM
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - Biomolecules, protein, oligonucleotides, NMR spectroscopy, computer simulations and modeling, protein engineering, DNA vaccines, bacteria %22quorum systems%22 (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...okUkonceniPodpory
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| http://linked.open...okZahajeniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...jektu+dodavatelem
| - Almost 90 scientific papers were published within the framework of the project (the average impact factor is about 4). More than 130 lectures were given on scientific meetings (56 out of them were invited lectures) and 93 posters were presented (en)
- V rámci řešení projektu bylo publikováno 88 prací převážně v časopisech s vysokým impact faktorem (průměrný impact faktor na publikaci se pohybuje kolem 4), bylo prezentováno 133 přednášek, z nichž 56 bylo pozvaných, a na konferencích bylo prezentováno 9 (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - Biomolecules
- DNA vaccines
- NMR spectroscopy
- oligonucleotides
- protein
- protein engineering
- computer simulations and modeling
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| is http://linked.open...vavai/riv/projekt
of | - Computational Study of Galactosyltransferase LgtC in Complex with Manganese Ion and Donor Substrate
- CV-IIL: New lectin from Chromobacterium violaceum
- Hinge-like motions in RNA kink-turn motifs
- Glycosyltransferasa LgtC: MD Simulace
- Homology Modelling of the Haloalkane Dehalogenase DhmA: Identification of Catalytic Residues.
- Haloalkane Dehalogenases from Parasitic Bacterium Mycobacterium bovis 5032/66.
- Medium-chain fatty acids decrease colonization and invasion shortly after infection with Salmonella Enteritidis in chickens through direct antimicrobial action and hilA suppression
- MD Simulation of Glycosyltransferase LgtC in Water and in Solution of NaCl
- Long-residency hydration, cation binding, and dynamics of loop E/helix IV rRNA-L25 protein complex
- Metal-mediated deamination of cytosine: experiment and DFT calculations
- Protein Engenneering of Enzymes
- NMR Studies of Purines
- Non-Watson-Crick base pairing in RNA. Quantum chemical analysis of the cis Watson-Crick/sugar edge base pair family
- Hinge-Like Motions in RNA Kink-Turns: The Role of the Second A-minor Motif and Nominally Unpaired Bases
- The fucose-binding lectin from Ralstonia solanacearum: a new type of beta-propeller architecture formed by oligomerisation and interacting with fucoside, fucosyllactose and plant xyloglucan
- Structural basis for the interaction between human milk oligosaccharides and a bacterial protein, Pseudomonas aeruginosa lectin PA-IIL,
- Elbow-like motions in Ribosomal Kink-turns: The role of the second A-minor motif and Nominally unpaired bases
- Degradation of b-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26.
- Gradient Inverse 15N NMR Spectroscopy of Nitrogen Heterocycles
- Free Bases of Benzophenanthridine Alkaloids - a Combined NMR, X-Ray and Theoretical Study
- Four novel germline BRCA1 and BRCA2 mutations in breast and breast-ovarian cancer
- Conformational Flexibility of Two RNA Trimers Explored by Computational Tools and Database Search
- Coordination number of zinc ions in the phosphotriesterase active site by molecular dynamics and quantum mechanics
- Cloning and characterization of a novel thermostable Mn(II)-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase from a PCB and naphthalene degrading Bacillus sp. JF8
- Combining fold recognition and exploratory data analysis for searching for glycosyltransferases in the genome of Mycobacterium tuberculosis
- Conformational Flexibility of DNA sequences studied by Advanced Molecular Mechanics and Dynamics Tools
- COMPUTER SIMULATIONS OF CYCLIN-DEPENDENT KINASE-2 NOTES ABOUT INHIBITION
- Cyclin-Dependent Protein Kinase-2 Regulation by Phosphorylation, A Molecular Dynamics Study
- Crystal structure of new lectin RS20L from Ralstonia solanacearum complexed with mannose ligand
- Interaction between Pseudomonas aeruginosa lectin PA-IIL and lung epithelia oligosaccharides
- Interaction entre la lectine PA-IIL de Pseudomonas aeruginosa et les oligosaccharides des epithelia pulmonaires
- Isolation and protein engeneering of bacterial enzymes haloalkan dehalogenas.
- INCREASED DYNAMICS OF MUP-I IN PRESENCE OF LIGAND: EVIDENCE FROM MD SIMULATION AND NMR SPIN RELAXATION
- Interactions of hydrated divalent metal cations with nucleic acid bases. How to relate the gas phase data to solution situation and binding selectivity in nucleic acids
- Kinetics and Specificity of Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26.
- Structures of the lectins from Pseudomonas aeruginosa: Insights into molecular basis for host glycan recognition
- Substrate specificity of haloalkane dehalogenases
- Studium vlivu intermolekulárních inetrakcí na 15N NMR chemické posuny derivátů 6-benzylaminopurinu
- Structure-functional studies of Ralstonia solanacearum lectins
- Struktura a interakce nukleových kyselin pohledem molekulové dynamiky
- NMR Study of Nucleic Acids In Supercooled Water
- Structure-Function Relationships and Protein Engineering of Dehalogenating Enzymes.
- Study of Structure and NMR Parameters of N-Substituted Purine Derivatives
- Statistical Evaluation of the Near Attack Conformers Population.
- Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG).
- A DFT Analysis of NMR Scalar Interactions Across the Glycosidic Bond in DNA
- Aleuria aurantia lectin displays novel binding mode for fucose. Crystal structure and ligand interaction of a new family of fucolectins.
- A Computer Program for the Simulation of the NOE Effect in NMR Spectroscopy, and Its Implementation into the CICADA Conformational Search Program
- A Computer Program for the Simulation of the NOE Effect in NMR Spectroscopy, and Its Implemetation into the CICADA Conformational Search Program
- A Novel Mechanism of Proton Transfer in Protonated Peptides
- Application of molecular modelling in nucleic acids and protein study
- Formation Pathways of a Guanine-Quadruplex DNA Revealed by Molecular Dynamics and Thermodynamics Analysis of the Substates
- Formation pathways of a guanine-quadruplex DNA revealed by molecular dynamics and thermodynamic analysis of the substates.
- Non-Watson-Crick Basepairing and Hydration in RNA Motifs:
- NEMESIS - molecular modelling package
- NMR Relaxation Studies of Fast Internal Motions in Nucleic Acids
- Non-Watson-Crick Base Pairing and Hydration in RNA motifs: Molecular Dynamics of 5S rRNA Loop E
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