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| rdf:type
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| Description
| - In this study, the medium-chain fatty acids (MCFA), caproic, caprylic, and capric acid, were evaluated for the control of Salmonella serovar Enteritidis in chickens. All MCFA were growth inhibiting at low concentrations in vitro, with caproic acid being the most potent. By using transcriptional fusions between the promoter of the regulatory gene of the Salmonella pathogenicity island I, hilA, and luxCDABE genes, it was shown that all MCFA decreased the expression of hilA, a key regulator related to the invasive capacity of Salmonella. The addition of caproic acid (3 g/kg of feed) to the feed of chicks led to a significant decrease in the level of colonization of ceca and internal organs by Salmonella serovar Enteritidis at 3 days after infection of 5-day-old chicks. These results suggest that MCFA have a synergistic ability to suppress the expression of the genes required for invasion and to reduce the numbers of bacteria in vivo.
- In this study, the medium-chain fatty acids (MCFA), caproic, caprylic, and capric acid, were evaluated for the control of Salmonella serovar Enteritidis in chickens. All MCFA were growth inhibiting at low concentrations in vitro, with caproic acid being the most potent. By using transcriptional fusions between the promoter of the regulatory gene of the Salmonella pathogenicity island I, hilA, and luxCDABE genes, it was shown that all MCFA decreased the expression of hilA, a key regulator related to the invasive capacity of Salmonella. The addition of caproic acid (3 g/kg of feed) to the feed of chicks led to a significant decrease in the level of colonization of ceca and internal organs by Salmonella serovar Enteritidis at 3 days after infection of 5-day-old chicks. These results suggest that MCFA have a synergistic ability to suppress the expression of the genes required for invasion and to reduce the numbers of bacteria in vivo. (en)
- V této práci byl hodnocen účinek mastných kyselin (MCFA) se střední délkou řetězce (C6, C8 a C10) na kolonizaci střevního traktu kuřat salmonelami. Všechny testované MCFA inhibovaly růst salmonel in vitro v nízkých koncentracích přičemž C6 MCFA byla nejúčinnější. S využitím transkripčních fúzí jsme zjistili, že MCFA snižovaly expresi genu hilA, který kóduje regulační protein klíčový pro invazi salmonel do eukaryotických buněk. Přídavek C6 MCFA ve výši 3 g/kg krmiva kuřat významně snížil kolonizaci střeva salmonelami u pětidenních kuřat. Tyto výsledky ukazují na synergistický efekt MCFA, které mají jak přímý antibakteriální účinek in vitro, tak i schopnost potlačit invazi salmonel do sliznice střevního traktu in vivo. (cs)
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| Title
| - Medium-chain fatty acids decrease colonization and invasion shortly after infection with Salmonella Enteritidis in chickens through direct antimicrobial action and hilA suppression
- C6, C8 a C10 mastné kyseliny snižují kolonizaci a invazi Salmonella Enteritidis u kuřat krátce po infekci díky jejich antimikrobiálnímu účinku a supresi hilA (cs)
- Medium-chain fatty acids decrease colonization and invasion shortly after infection with Salmonella Enteritidis in chickens through direct antimicrobial action and hilA suppression (en)
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| skos:prefLabel
| - Medium-chain fatty acids decrease colonization and invasion shortly after infection with Salmonella Enteritidis in chickens through direct antimicrobial action and hilA suppression
- C6, C8 a C10 mastné kyseliny snižují kolonizaci a invazi Salmonella Enteritidis u kuřat krátce po infekci díky jejich antimikrobiálnímu účinku a supresi hilA (cs)
- Medium-chain fatty acids decrease colonization and invasion shortly after infection with Salmonella Enteritidis in chickens through direct antimicrobial action and hilA suppression (en)
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| skos:notation
| - RIV/00027162:_____/04:#0000149!RIV08-MSM-00027162
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/04:#0000149
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Salmonella; hilA; MCFA; Chicken (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Applied and Environmental Microbiology
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
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| issn
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| number of pages
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