About: Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bifunctional chelating ligands (BFC) sequestering radiometal ions are used in radioimunotherapy and diagnosis. BFC contain metal coordination unit (e.g. macrocycle) attached to biologically active molecules, e.g. monoclonal antibodies, small peptides, hormones, sugars, etc. The complexes should exhibit high thermodynamic stability and, of course, kinetic inertness under physiological conditions. Both properties are strongly influenced by degree of derivatization of macrocyclic skeleton and type of linker attached to biomolecule. In this contribution, the influence of structural variation of linker of BFC on kinetic properties was studied. Under experimental conditions (t = 25 oC, I = 0.1 M KCl, pH = 5.6-7.1, cY = 710-7 M, cL = 1.610-5 M), which are closed to conditions of 90Y radiolabelling in nuclear medicine, the empirical order in reactivity in respect to yttrium(III) was obtained: DO3AP > DO3APPrA > DOTA > DO3A > DO3APABn The results of complexation kinetics were compared with data obtained f Bifunctional chelating ligands (BFC) sequestering radiometal ions are used in radioimunotherapy and diagnosis. BFC contain metal coordination unit (e.g. macrocycle) attached to biologically active molecules, e.g. monoclonal antibodies, small peptides, hormones, sugars, etc. The complexes should exhibit high thermodynamic stability and, of course, kinetic inertness under physiological conditions. Both properties are strongly influenced by degree of derivatization of macrocyclic skeleton and type of linker attached to biomolecule. In this contribution, the influence of structural variation of linker of BFC on kinetic properties was studied. Under experimental conditions (t = 25 oC, I = 0.1 M KCl, pH = 5.6-7.1, cY = 710-7 M, cL = 1.610-5 M), which are closed to conditions of 90Y radiolabelling in nuclear medicine, the empirical order in reactivity in respect to yttrium(III) was obtained: DO3AP > DO3APPrA > DOTA > DO3A > DO3APABn The results of complexation kinetics were compared with data obtained f (en)
Title	Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands (en)
skos:prefLabel	Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands (en)
skos:notation	RIV/00216224:14310/03:00008745!RIV/2004/GA0/143104/N
http://linked.open.../vavai/riv/strany	CO-P10
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/02/0493), P(GA203/03/0168), Z(MSM 143100011)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Lukeš, Ivan Voráčová, Ivona Hermann, Petr Lubal, Přemysl Táborský, Petr
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	601661
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/03:00008745
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bifunctional chelating ligands, DOTA-like macrocyclic ligands, yttrium(III) (en)
http://linked.open.../riv/klicoveSlovo	DOTA-like macrocyclic ligands bifunctional chelating ligands yttrium(III)
http://linked.open...ontrolniKodProRIV	[954E60DB73E5]
http://linked.open...i/riv/mistoVydani	Geneve
http://linked.open...i/riv/nazevZdroje	Book of Abstracts of 5-th International Conference on f-elements - ICFE5. Geneva, Switzerland, August 24-29, 2003
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Bifunctional chelates. Synthesis and complexing properties Kinetically Inert Complexes of Transition Metal and Lanthanide Ions. Design, Synthesis and Kinetic Investigations
http://linked.open...UplatneniVysledku	2003
http://linked.open...iv/tvurceVysledku	Hermann, Petr Lubal, Přemysl Lukeš, Ivan Svobodová, Ivona Táborský, Petr Málková, Michaela
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143100011
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	SYMPORG SA
http://localhost/t...ganizacniJednotka	14310

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