About: Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis

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About: Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Completion of DNA replication needs to be ensured even when challenged with fork progression problems or DNA damage. PCNA and its modifications constitute a molecular switch to control distinct repair pathways. In yeast, SUMOylated PCNA (S-PCNA) recruits Srs2 to sites of replication where Srs2 can disrupt Rad51 filaments and prevent homologous recombination (HR). We report here an unexpected additional mechanism by which S-PCNA and Srs2 block the synthesis-dependent extension of a recombination intermediate, thus limiting its potentially hazardous resolution in association with a cross-over. This new Srs2 activity requires the SUMO interaction motif at its C-terminus, but neither its translocase activity nor its interaction with Rad51. Srs2 binding to S-PCNA dissociates Pol delta and Pol eta from the repair synthesis machinery, thus revealing a novel regulatory mechanism controlling spontaneous genome rearrangements. Completion of DNA replication needs to be ensured even when challenged with fork progression problems or DNA damage. PCNA and its modifications constitute a molecular switch to control distinct repair pathways. In yeast, SUMOylated PCNA (S-PCNA) recruits Srs2 to sites of replication where Srs2 can disrupt Rad51 filaments and prevent homologous recombination (HR). We report here an unexpected additional mechanism by which S-PCNA and Srs2 block the synthesis-dependent extension of a recombination intermediate, thus limiting its potentially hazardous resolution in association with a cross-over. This new Srs2 activity requires the SUMO interaction motif at its C-terminus, but neither its translocase activity nor its interaction with Rad51. Srs2 binding to S-PCNA dissociates Pol delta and Pol eta from the repair synthesis machinery, thus revealing a novel regulatory mechanism controlling spontaneous genome rearrangements. (en)
Title	Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis (en)
skos:prefLabel	Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis (en)
skos:notation	RIV/00216224:14110/13:00066406!RIV14-MSM-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123), P(GA13-26629S), P(GA301/09/1917), P(GAP207/12/2323), P(GD203/09/H046), P(ME10048)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Sisáková, Alexandra Šebesta, Marek Marini Palomeque, María Victoria Krejčí, Lumír Kolesár, Peter Burkovics, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	107357
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00066406
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA repair synthesis; genome stability; PCNA SUMOylation; Srs2; SUMO interacting motif (en)
http://linked.open.../riv/klicoveSlovo	genome stability DNA repair synthesis PCNA SUMOylation SUMO interacting motif Srs2
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[793B648EAFA1]
http://linked.open...i/riv/nazevZdroje	EMBO JOURNAL
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Biochemistry on the crossroad from in silico to in vitro Endonuclease and translocase activity in type I restriction-modification complexes St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC) Resolution of replication-recombination DNA intermediates and its role in genomic instability The role of post-translational modification in DNA repair and recombination: Meiosis, SUMOylation and Zip3 protein SUMO a stability genomu
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Krejčí, Lumír Kolesár, Peter Marini Palomeque, María Victoria Sisáková, Alexandra Šebesta, Marek Burkovics, Peter Haracska, Lajos Gangloff, Serge Pinter, Lajos Plault, Nicolas Robert, Thomas Szukacsov, Valeria
http://linked.open...ain/vavai/riv/wos	000316468000014
issn	0261-4189
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/emboj.2013.9
http://localhost/t...ganizacniJednotka	14110

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