About: Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Evidence has recently indicated that the MRAS and HNF1A genetic polymorphisms are associated with coronary artery disease. The MRAS and HNF1A genes are located on chromosomes 3q and 12q within the regions where associations with diabetes and diabetic nephropathy occur. We thus performed genetic and functional analyses of these two genes to evaluate their impacts on diabetes and diabetic nephropathy. MRAS and HNF1A genetic polymorphisms were genotyped in 1399 Czech subjects including non-diabetic controls (339), type 1 (243) and type 2 (817) diabetic patients with and without diabetic nephropathy using TaqMan allelic discrimination. Gene expression levels in the kidneys of diabetic Goto-Kakizaki and Wistar rats were detected with real-time RT-PCR. Despite no significance in genetic analysis of diabetic subjects, SNP rs2259816 in the HNF1A gene tended to associate with diabetic nephropathy in type 1 diabetic patients. Evidence has recently indicated that the MRAS and HNF1A genetic polymorphisms are associated with coronary artery disease. The MRAS and HNF1A genes are located on chromosomes 3q and 12q within the regions where associations with diabetes and diabetic nephropathy occur. We thus performed genetic and functional analyses of these two genes to evaluate their impacts on diabetes and diabetic nephropathy. MRAS and HNF1A genetic polymorphisms were genotyped in 1399 Czech subjects including non-diabetic controls (339), type 1 (243) and type 2 (817) diabetic patients with and without diabetic nephropathy using TaqMan allelic discrimination. Gene expression levels in the kidneys of diabetic Goto-Kakizaki and Wistar rats were detected with real-time RT-PCR. Despite no significance in genetic analysis of diabetic subjects, SNP rs2259816 in the HNF1A gene tended to associate with diabetic nephropathy in type 1 diabetic patients. (en)
Title	Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy (en)
skos:prefLabel	Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy (en)
skos:notation	RIV/00216224:14110/12:00064926!RIV13-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NT11405), Z(MSM0021620807)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kaňková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	137890
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/12:00064926
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MRAS; HNF1A; diabetic nephropathy; type 1 and 2 diabetes (en)
http://linked.open.../riv/klicoveSlovo	MRAS HNF1A type 1 and 2 diabetes diabetic nephropathy
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2F6984A079B9]
http://linked.open...i/riv/nazevZdroje	Folia biologica
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Microbiologic and genetic determinants of the onset and progression of periodontitis in type 1 and 2 diabetics and their reciprocal relationship to diabetes compensation
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Kaňková, Kateřina Brismar, K. Gu, H. F. Horova, Eva Prazny, Michal
http://linked.open...ain/vavai/riv/wos	000306098400005
http://linked.open...n/vavai/riv/zamer	Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění
issn	0015-5500
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy

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