About: Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The cytoskeleton was investigated as a potential target for the inhibition of cell division in Fellomyces fuzhou-ensis related to Cryptococcus neoformans.Vincristine, vinblastine,paclitaxel,methyl benzimidazole-2-yl carbamate (BCM),thiabendazole,cytochalasins A,B,D and latrunculin A were added to cells and investigated.Vincristine, vinblastine, paclitaxel, cytochalasins A,B and D transiently blocked proliferation. BCM disrupted microtubules,inhibited mitosis, but F-actin structures persisted and neck-less conidia originated. Latrunculin disrupted F-actin, cells became spherical,stalks and necks degenerated, microtubules persisted,mitosis,cytokinesis and conidiogenesis were blocked.The combined application of latrunculin and BCM disrupted F-actin and microtubules,inhibited cells became spherical and did not divide.Conclusion: Microtubules and F-actin are effective targets for permanent inhibition of nuclear and cell division and conidiogenesis by BCM and latrunculin A. The cytoskeleton was investigated as a potential target for the inhibition of cell division in Fellomyces fuzhou-ensis related to Cryptococcus neoformans.Vincristine, vinblastine,paclitaxel,methyl benzimidazole-2-yl carbamate (BCM),thiabendazole,cytochalasins A,B,D and latrunculin A were added to cells and investigated.Vincristine, vinblastine, paclitaxel, cytochalasins A,B and D transiently blocked proliferation. BCM disrupted microtubules,inhibited mitosis, but F-actin structures persisted and neck-less conidia originated. Latrunculin disrupted F-actin, cells became spherical,stalks and necks degenerated, microtubules persisted,mitosis,cytokinesis and conidiogenesis were blocked.The combined application of latrunculin and BCM disrupted F-actin and microtubules,inhibited cells became spherical and did not divide.Conclusion: Microtubules and F-actin are effective targets for permanent inhibition of nuclear and cell division and conidiogenesis by BCM and latrunculin A. (en)
Title	Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals (en)
skos:prefLabel	Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals (en)
skos:notation	RIV/00216224:14110/09:00029343!RIV11-GA0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA310/00/0391), P(GA310/03/1195), P(GA310/06/0605)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Gabriel, Miroslav Kopecká, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	326355
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/09:00029343
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Yeast; Actin; Microtubules; Paclitaxel; Vincristine; Vinblastine; Methyl benzimidazole2yl carbamate; Thiabendazole; Cytochalasins A B D; Latrunculin A (en)
http://linked.open.../riv/klicoveSlovo	Vinblastine Actin Paclitaxel Latrunculin A Microtubules Yeast Cytochalasins A B D Methyl benzimidazole2yl carbamate Vincristine Thiabendazole
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[1E36EC01211F]
http://linked.open...i/riv/nazevZdroje	CHEMOTHERAPY
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Human pathogenic fungi : the cytoskeleton as a potential target of inhibition of morphogenesis. Cytoskeleton in human pathogenic yeast microorganisms The cytoskeleton as the target structure for the study of the effect of antifungal agents on pathogenic yeasts
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Kopecká, Marie Gabriel, Miroslav
http://linked.open...ain/vavai/riv/wos	000266883400013
issn	0009-3157
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software