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Description
| - The connection between chimerism status and occurence of relapse in patients undergoing hematopoietic stem cell transplantation remains controversial. One reason for this seems to be employment of different methods with inherrited different sensitivity and related definition of complete donor chimerism (CDC). We compared an application of fragment analysis (FA) of minisatellite, microsatellite or sex specific regions (limit of quantification 1%) with real-time quantitative PCR (RQ-PCR) of insertion/deletion and sex polymorphism (limit of quantification 0.1%). Long-term data (follow-up 1.8-7.4 years, median 3.3 years) obtained from two groups of AML patients transplanted in our centre are presented. The first group involves 9 patients that experienced relapse (one of them three times) whereas the second one contains 11 individuals in complete remission. Retrospective chimerism analysis of patients in the first group by RQ-PCR allowed prediction of hematological relapse significantly earlier (p=0.
- The connection between chimerism status and occurence of relapse in patients undergoing hematopoietic stem cell transplantation remains controversial. One reason for this seems to be employment of different methods with inherrited different sensitivity and related definition of complete donor chimerism (CDC). We compared an application of fragment analysis (FA) of minisatellite, microsatellite or sex specific regions (limit of quantification 1%) with real-time quantitative PCR (RQ-PCR) of insertion/deletion and sex polymorphism (limit of quantification 0.1%). Long-term data (follow-up 1.8-7.4 years, median 3.3 years) obtained from two groups of AML patients transplanted in our centre are presented. The first group involves 9 patients that experienced relapse (one of them three times) whereas the second one contains 11 individuals in complete remission. Retrospective chimerism analysis of patients in the first group by RQ-PCR allowed prediction of hematological relapse significantly earlier (p=0. (en)
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Title
| - Chimerism status as a possible marker of incipient disease relapse in patients with AML
- Chimerism status as a possible marker of incipient disease relapse in patients with AML (en)
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skos:prefLabel
| - Chimerism status as a possible marker of incipient disease relapse in patients with AML
- Chimerism status as a possible marker of incipient disease relapse in patients with AML (en)
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skos:notation
| - RIV/00216224:14110/07:00025698!RIV10-MSM-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/07:00025698
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - microchimerism; RQ-PCR; relapse (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Dvořáková, Dana
- Horký, Ondřej
- Krejčí, Marta
- Mayer, Jiří
- Pospíšilová, Šárka
- Borský, Marek
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http://linked.open...vavai/riv/typAkce
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http://linked.open...ain/vavai/riv/wos
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http://linked.open.../riv/zahajeniAkce
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://purl.org/ne...btex#hasPublisher
| - American Society of Hematology
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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