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  • DNA of Treponema pallidum subsp. pallidum Nichols strain was compared to DNA isolated from three different strains of T. pallidum subsp. pertenue (strain Gauthier, Samoan D, CDC-2). As a result of DNA microarray comparisons, 25 genes (13 with stronger and 6 with weaker signal in pertenue strains and 6 control genes with similar signal in both subspecies examined) were selected and sequenced. Altogether, 24083 nucleotides (2.12% of the genome) were sequenced in 3 pertenue strains and control Nichols. No region of extensive sequence heterogeneity was detected. However, 15 different single nucleotide polymorfisms (SNP) were identified: 3 SNPs in Gauthier strain, 14 in Samoan D and 15 SNPs in CDC-2. Ten (out of 15) SNPs cause amino acid changes. SNPs common for all pertenue strains as well as SNPs specific for each individual strain will allow to use these nucleotide polymorfisms to design sequence specific PCR diagnostics of these strains.
  • DNA of Treponema pallidum subsp. pallidum Nichols strain was compared to DNA isolated from three different strains of T. pallidum subsp. pertenue (strain Gauthier, Samoan D, CDC-2). As a result of DNA microarray comparisons, 25 genes (13 with stronger and 6 with weaker signal in pertenue strains and 6 control genes with similar signal in both subspecies examined) were selected and sequenced. Altogether, 24083 nucleotides (2.12% of the genome) were sequenced in 3 pertenue strains and control Nichols. No region of extensive sequence heterogeneity was detected. However, 15 different single nucleotide polymorfisms (SNP) were identified: 3 SNPs in Gauthier strain, 14 in Samoan D and 15 SNPs in CDC-2. Ten (out of 15) SNPs cause amino acid changes. SNPs common for all pertenue strains as well as SNPs specific for each individual strain will allow to use these nucleotide polymorfisms to design sequence specific PCR diagnostics of these strains. (en)
  • Byly vyšetřeny kmeny Treponema pallidum subsp. pallidum (původce syfilis) a T. pallidum subsp. pertenue (původce yaws) pomocí DNA-microarray techniky a genomového sekvenování. Zjištěné rozdíly byly diskutovány v kontextu současných poznatků. (cs)
Title
  • Comparative genomics of pathogenic Treponema pallidum subspecies
  • Comparative genomics of pathogenic Treponema pallidum subspecies (en)
  • Komparativní genomika patogenních poddruhů Treponema pallidum (cs)
skos:prefLabel
  • Comparative genomics of pathogenic Treponema pallidum subspecies
  • Comparative genomics of pathogenic Treponema pallidum subspecies (en)
  • Komparativní genomika patogenních poddruhů Treponema pallidum (cs)
skos:notation
  • RIV/00216224:14110/03:00012312!RIV/2005/MZ0/141105/N
http://linked.open.../vavai/riv/strany
  • 297-298
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NI7351)
http://linked.open...iv/cisloPeriodika
  • 97
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 601652
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/03:00012312
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • comparative genomics, Treponema pallidum (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [0C705A093CD4]
http://linked.open...i/riv/nazevZdroje
  • CHEMICKÉ LISTY
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2003
http://linked.open...iv/tvurceVysledku
  • Matějková, Petra
  • Šmajs, David
  • Norris, S. J.
  • Weinstock, G. M.
issn
  • 0009-2770
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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