About: Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6.

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About: Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ubiquitous solute carriers 11 (SLC11) contribute to metal-ion homeostasis by importing Me(2+) and H(+) into the cytoplasm. To identify residues mediating cation symport, Escherichia coli proton-dependent manganese transporter (MntH) was mutated at five SLC11-specific transmembrane (TM) sites; each mutant activity was compared with wild-type MntH, and the biochemical results were tested by homology threading. Cd(2+) and H(+) uptake kinetics were analyzed in whole cells as a function of pH and temperature, and right-side out membrane vesicles were used to detail energy requirements and to probe site accessibility by Cys replacement and thiol modification. This approach revealed that... Ubiquitous solute carriers 11 (SLC11) contribute to metal-ion homeostasis by importing Me(2+) and H(+) into the cytoplasm. To identify residues mediating cation symport, Escherichia coli proton-dependent manganese transporter (MntH) was mutated at five SLC11-specific transmembrane (TM) sites; each mutant activity was compared with wild-type MntH, and the biochemical results were tested by homology threading. Cd(2+) and H(+) uptake kinetics were analyzed in whole cells as a function of pH and temperature, and right-side out membrane vesicles were used to detail energy requirements and to probe site accessibility by Cys replacement and thiol modification. This approach revealed that... (en) Ubiquitous solute carriers 11 (SLC11) contribute to metal-ion homeostasis by importing Me(2+) and H(+) into the cytoplasm. To identify residues mediating cation symport, Escherichia coli proton-dependent manganese transporter (MntH) was mutated at five SLC11-specific transmembrane (TM) sites; each mutant activity was compared with wild-type MntH, and the biochemical results were tested by homology threading. Cd(2+) and H(+) uptake kinetics were analyzed in whole cells as a function of pH and temperature, and right-side out membrane vesicles were used to detail energy requirements and to probe site accessibility by Cys replacement and thiol modification. This approach revealed that... (cs)
Title	Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. (en) Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. (cs)
skos:prefLabel	Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. (en) Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. (cs)
skos:notation	RIV/00216208:11320/08:00100281!RIV09-MSM-11320___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/07/0558), Z(MSM0021620835)
http://linked.open...iv/cisloPeriodika	15
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Chaloupka, Roman Urbánková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Matematicko-fyzikální fakulta
http://linked.open...dnocenehoVysledku	395828
http://linked.open...ai/riv/idVysledku	RIV/00216208:11320/08:00100281
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Solute; carrier; cation; symport; requires; distinct; residues; transmembrane; helices (en)
http://linked.open.../riv/klicoveSlovo	carrier residues Solute cation distinct helices requires symport transmembrane
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[AFB0D81695C2]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Biophysical study of MntH membrane transport proteins: structure-function relationship
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	283
http://linked.open...iv/tvurceVysledku	Chaloupka, Roman Urbánková, Eva Cellier, Mathieu Courville, Pascal Quick, Matthias Rensing, Christopher
http://linked.open...ain/vavai/riv/wos	000254671600019
http://linked.open...n/vavai/riv/zamer	Fyzika molekulárních, makromolekulárních a biologických systémů
issn	0021-9258
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11320
is http://linked.open...avai/riv/vysledek of	Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6.

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