About: Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors

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About: Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.3389/fncel.2014.00375
Description	N-methyl-D-aspartate (NMDA) receptors mediate fast excitatory synaptic transmission in the mammalian central nervous system. The activation of NMDA receptors plays a key role in brain development, synaptic plasticity, and memory formation, and is a major contributor to many neuropsychiatric disorders. Here, we investigated the mechanisms that underlie the trafficking of GluN1/GluN2C receptors. Using an approach combining molecular biology, microscopy, and electrophysiology in mammalian cell lines and cultured cerebellar granule cells, we found that the surface delivery of GluN2C-containing receptors is reduced compared to GluN2A- and GluN2B-containing receptors. Furthermore, we identified three distinct regions within the N-terminus, M3 transmembrane domain, and C-terminus of GluN2C subunits that are required for proper intracellular processing and surface delivery of NMDA receptors. These results shed new light on the regulation of NMDA receptor trafficking, and these findings can be exploited to develop new strategies for treating some forms of neuropsychiatric disorders. N-methyl-D-aspartate (NMDA) receptors mediate fast excitatory synaptic transmission in the mammalian central nervous system. The activation of NMDA receptors plays a key role in brain development, synaptic plasticity, and memory formation, and is a major contributor to many neuropsychiatric disorders. Here, we investigated the mechanisms that underlie the trafficking of GluN1/GluN2C receptors. Using an approach combining molecular biology, microscopy, and electrophysiology in mammalian cell lines and cultured cerebellar granule cells, we found that the surface delivery of GluN2C-containing receptors is reduced compared to GluN2A- and GluN2B-containing receptors. Furthermore, we identified three distinct regions within the N-terminus, M3 transmembrane domain, and C-terminus of GluN2C subunits that are required for proper intracellular processing and surface delivery of NMDA receptors. These results shed new light on the regulation of NMDA receptor trafficking, and these findings can be exploited to develop new strategies for treating some forms of neuropsychiatric disorders. (en)
Title	Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors (en)
skos:prefLabel	Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors (en)
skos:notation	RIV/00216208:11310/14:10288747!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0109), P(GA14-02219S), P(GAP303/12/1464), P(GP14-09220P), S
http://linked.open...iv/cisloPeriodika	November
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Lichnerová, Katarina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	11805
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/14:10288747
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	endoplasmic reticulum; cerebellar granule cells; electrophysiology; intracellular trafficking; ion channel; glutamate receptor (en)
http://linked.open.../riv/klicoveSlovo	cerebellar granule cells endoplasmic reticulum intracellular trafficking electrophysiology glutamate receptor ion channel
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[310E59E56F84]
http://linked.open...i/riv/nazevZdroje	Frontiers in Cellular Neuroscience
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Regulace transportu a funkce NMDA receptorů N-glykosylací Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University Neurosteroid modulation of NMDA receptors Structural and functional determinants of NMDA receptor trafficking
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Kaniakova, Martina Horak, Martin Lichnerová, Katarína Skrenkova, Kristyna Vyklicky, Ladislav
http://linked.open...ain/vavai/riv/wos	000344540900001
issn	1662-5102
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.3389/fncel.2014.00375
http://localhost/t...ganizacniJednotka	11310

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