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Description
  • To involve students in thinking about the problem of AIDS (which is important in the view of non-decreasing infection rates) we established a practical lab using a simplified method of Thomas (2004) to determine the polymorphism of HIV co-receptor CCR5 from students' own epithelial cells. CCR5 is a receptor involved in inflammatory processes, which has been misused by some pathogens, including HIV, to enter host cells. As a result, a defective allele CCR5-Δ32 has been enriched in some populations. Due to the interesting story and hands-on work with their own tissue students were absorbed by this 2 hour practical.
  • To involve students in thinking about the problem of AIDS (which is important in the view of non-decreasing infection rates) we established a practical lab using a simplified method of Thomas (2004) to determine the polymorphism of HIV co-receptor CCR5 from students' own epithelial cells. CCR5 is a receptor involved in inflammatory processes, which has been misused by some pathogens, including HIV, to enter host cells. As a result, a defective allele CCR5-Δ32 has been enriched in some populations. Due to the interesting story and hands-on work with their own tissue students were absorbed by this 2 hour practical. (en)
Title
  • A simplified technique for evaluating human CCR5 genetic polymorphism
  • A simplified technique for evaluating human CCR5 genetic polymorphism (en)
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  • A simplified technique for evaluating human CCR5 genetic polymorphism
  • A simplified technique for evaluating human CCR5 genetic polymorphism (en)
skos:notation
  • RIV/00216208:11310/13:10173228!RIV14-MSM-11310___
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  • I, P(1M0506), Z(MSM0021620858)
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  • 59070
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  • RIV/00216208:11310/13:10173228
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  • secondary school; polymorphism; genotyping; HIV resistance; CCR5; polymerase chain reaction; PCR (en)
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  • [085ACCF7ED0C]
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  • Černý, Jan
  • Falteisek, Lukáš
  • Janštová, Vanda
http://linked.open...n/vavai/riv/zamer
http://bibframe.org/vocab/doi
  • 10.1525/abt.2013.75.9.13
http://localhost/t...ganizacniJednotka
  • 11310
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