About: Determination of Aminoglutethimide Using HPLC-ED on CPE

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.bestservis.eu/Rakce/lang
Description	This work deals with the determination of aminoglutethimide (AGT) using high performance liquid chromatography with UV spectrophotometric detection (HPLC-UV) and amperometric detection (HPLC-ED) on carbon paste electrode (CPE). AGT was used as anticancer drug, especially for the treatment of breast cancer in postmenopausal women or for the treatment of prostate cancer. The concentration dependences of AGT were measured by HPLC-UV with detection wavelength 242 nm, by HPLC-ED with a working potencial of +1.3 V in mobile phase consisting of 1.10-2 mol l-1 phosphate buffer (pH 4) and methanol 50:50 (v/v). The following limits of detection were achieved : 3.6.10-7 mol l-1 AGT for UV spectrophotometric detection, 2.5.10-7 mol l-1 AGT for amperometric detection. AGT was also determined in model samples of urine. It was not possible to detect AGT with HPLC-UV, because of the interferences of other compounds. With HPLC-ED the detection limit 5.2.10-7 mol l-1 AGT was achieved. This work deals with the determination of aminoglutethimide (AGT) using high performance liquid chromatography with UV spectrophotometric detection (HPLC-UV) and amperometric detection (HPLC-ED) on carbon paste electrode (CPE). AGT was used as anticancer drug, especially for the treatment of breast cancer in postmenopausal women or for the treatment of prostate cancer. The concentration dependences of AGT were measured by HPLC-UV with detection wavelength 242 nm, by HPLC-ED with a working potencial of +1.3 V in mobile phase consisting of 1.10-2 mol l-1 phosphate buffer (pH 4) and methanol 50:50 (v/v). The following limits of detection were achieved : 3.6.10-7 mol l-1 AGT for UV spectrophotometric detection, 2.5.10-7 mol l-1 AGT for amperometric detection. AGT was also determined in model samples of urine. It was not possible to detect AGT with HPLC-UV, because of the interferences of other compounds. With HPLC-ED the detection limit 5.2.10-7 mol l-1 AGT was achieved. (en)
Title	Determination of Aminoglutethimide Using HPLC-ED on CPE Determination of Aminoglutethimide Using HPLC-ED on CPE (en)
skos:prefLabel	Determination of Aminoglutethimide Using HPLC-ED on CPE Determination of Aminoglutethimide Using HPLC-ED on CPE (en)
skos:notation	RIV/00216208:11310/11:10105116!RIV12-MSM-11310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(LC06035), P(ME10004), S, Z(MSM0021620857)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Dejmková, Hana Zima, Jiří Vlachová, Karolína Barek, Jiří
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	193800
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/11:10105116
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	amperometric detection; spectrophotometric detection; HPLC; carbon paste electrode; Aminoglutethimide (en)
http://linked.open.../riv/klicoveSlovo	Aminoglutethimide amperometric detection carbon paste electrode spectrophotometric detection HPLC
http://linked.open...ontrolniKodProRIV	[55D50107EB2A]
http://linked.open...v/mistoKonaniAkce	Jetřichovice
http://linked.open...i/riv/mistoVydani	Ústí nad Labem
http://linked.open...i/riv/nazevZdroje	Moderní elektrochemické metody: sborník přednášek XXXI. mezinárodní odborné konference: Jetřichovice 23. – 27. května 2011
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine. New electrode materials for voltammetric and amperometric detection of trace amounts of ecotoxic and genotoxic organic pollutants
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Barek, Jiří Dejmková, Hana Vlachová, Karolína Zima, Jiří
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2011-05-23 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	BEST servis Ústí nad Labem
https://schema.org/isbn	978-80-254-9634-3
http://localhost/t...ganizacniJednotka	11310
is http://linked.open...avai/riv/vysledek of	Determination of Aminoglutethimide Using HPLC-ED on CPE Determination of Aminoglutethimide Using HPLC-ED on CPE

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