About: Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis     Goto   Sponge   NotDistinct   Permalink

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  • Increased serum prolactin (PRL) levels have been demonstrated in several autoimmune diseases including polymyositis (PM) and systemic sclerosis (SSc). Its extrapituitary promoter contains functional single nucleotide polymorphism (SNP) -1149 G/T in the GATA sequence; G allele leads to higher PRL mRNA in lymphocytes synthesis. We looked for distribution of allele and genotype of the -1149 G/T SNP of the extrapituitary PRL promoter in 75 patients with SSc, in 47 subjects with PM, in 68 patients with dermatomyositis (DM), and in 123 healthy Czech subjects. The genotype and allele distribution did not show any significant differences in groups of PM, DM, and SSc patients compared to healthy individuals. We found a significant inverse association between TT genotype in SSc patients with disease onset after 45 years compared to individuals with SSc and diseases onset prior to 45 years.
  • Increased serum prolactin (PRL) levels have been demonstrated in several autoimmune diseases including polymyositis (PM) and systemic sclerosis (SSc). Its extrapituitary promoter contains functional single nucleotide polymorphism (SNP) -1149 G/T in the GATA sequence; G allele leads to higher PRL mRNA in lymphocytes synthesis. We looked for distribution of allele and genotype of the -1149 G/T SNP of the extrapituitary PRL promoter in 75 patients with SSc, in 47 subjects with PM, in 68 patients with dermatomyositis (DM), and in 123 healthy Czech subjects. The genotype and allele distribution did not show any significant differences in groups of PM, DM, and SSc patients compared to healthy individuals. We found a significant inverse association between TT genotype in SSc patients with disease onset after 45 years compared to individuals with SSc and diseases onset prior to 45 years. (en)
Title
  • Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis
  • Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis (en)
skos:prefLabel
  • Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis
  • Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis (en)
skos:notation
  • RIV/00216208:11310/10:10080384!RIV13-MSM-11310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V, Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika
  • 12
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 279794
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/10:10080384
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • polymorphism; gene; prolactin; systemic sclerosis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [100704D12999]
http://linked.open...i/riv/nazevZdroje
  • Rheumatology International
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 30
http://linked.open...iv/tvurceVysledku
  • Vencovský, Jiří
  • Černá, Marie
  • Čejková, Pavlína
  • Fojtíková, Markéta
  • Bečvář, Radim
  • Tomasová-studýnk, Jana
http://linked.open...ain/vavai/riv/wos
  • 000283503200027
http://linked.open...n/vavai/riv/zamer
issn
  • 0172-8172
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/s00296-009-1284-x
http://localhost/t...ganizacniJednotka
  • 11310
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