About: Bone-seeking probes for optical and magnetic resonance imaging

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In clinical practice the imaging of bone tissue is based almost exclusively on x-ray or radiochemical methods. Alternative methods, such as MRI and optical imaging, can provide not only anatomical, but also physiological information, due to their ability to reflect the properties of body fluids (temperature, pH and concentration of ions). In this article we review bone targeting probes for MRI and fluorescence imaging. As bone targeting is mainly associated with phosphonate and bisphosphonate derivatives, we also focus on their sorption behavior. Also discussed in detail is the limitation of using bone-targeting probes for MRI and optical imaging mainly due to their long-time retention in bone tissue and the low permeability of tissues for light. In clinical practice the imaging of bone tissue is based almost exclusively on x-ray or radiochemical methods. Alternative methods, such as MRI and optical imaging, can provide not only anatomical, but also physiological information, due to their ability to reflect the properties of body fluids (temperature, pH and concentration of ions). In this article we review bone targeting probes for MRI and fluorescence imaging. As bone targeting is mainly associated with phosphonate and bisphosphonate derivatives, we also focus on their sorption behavior. Also discussed in detail is the limitation of using bone-targeting probes for MRI and optical imaging mainly due to their long-time retention in bone tissue and the low permeability of tissues for light. (en)
Title	Bone-seeking probes for optical and magnetic resonance imaging Bone-seeking probes for optical and magnetic resonance imaging (en)
skos:prefLabel	Bone-seeking probes for optical and magnetic resonance imaging Bone-seeking probes for optical and magnetic resonance imaging (en)
skos:notation	RIV/00216208:11310/10:10054458!RIV11-MSM-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KAN201110651), P(OC 179), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Lukeš, Ivan Kubíček, Vojtěch
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	249122
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/10:10054458
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hydroxyapatite; bone tissue; phosphonates; contrast agents; probes; optical imaging; magnetic resonance imaging (en)
http://linked.open.../riv/klicoveSlovo	optical imaging probes bone tissue hydroxyapatite magnetic resonance imaging phosphonates contrast agents
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[137596469385]
http://linked.open...i/riv/nazevZdroje	Future medicinal chemistry
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20179 Combined contrast agents for molecular MR imaging
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Kubíček, Vojtěch Lukeš, Ivan
http://linked.open...ain/vavai/riv/wos	000276132000021
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	1756-8919
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11310
is http://linked.open...avai/riv/vysledek of	Bone-seeking probes for optical and magnetic resonance imaging Bone-seeking probes for optical and magnetic resonance imaging Bone-seeking probes for optical and magnetic resonance imaging

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