About: Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

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About: Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ellipticine is an antineoplastic agent, which forms covalent DNA adducts mediated by cytochromes P450 and peroxidases. We evaluated the role of hepatic versus extra-hepatic metabolism of ellipticine, using the Hepatic Cytochrome P450 Reductase Null mouse Ellipticine is an antineoplastic agent, which forms covalent DNA adducts mediated by cytochromes P450 and peroxidases. We evaluated the role of hepatic versus extra-hepatic metabolism of ellipticine, using the Hepatic Cytochrome P450 Reductase Null mouse (en) Ellipticin tvoří kovalentní adukty s DNA, po aktivaci cvytochromy P450 a peroxidasami. Byla porovnána role jaterního a mimojaterního metabolismu použitím s cytochrom P450 reduktaza deficientního myšího modelu. (cs)
Title	Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse Role jaterních cytochromů P450 při biotransformaci protinádorového léčiva ellipticinu (cs) Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse (en)
skos:prefLabel	Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse Role jaterních cytochromů P450 při biotransformaci protinádorového léčiva ellipticinu (cs) Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse (en)
skos:notation	RIV/00216208:11310/08:13541!RIV09-MSM-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0505), P(GA203/06/0329), Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Moserová, Michaela Kotrbová, Věra Hudeček, Jiří Stiborová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	393184
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/08:13541
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	anticancer drug; ellipticine; cytochrome P450; peroxidase; DNA adducts; P-32-postlabelling; dna adduct formation; prostaglandin-h synthase; environmental-pollutant 3-nitrobenzanthrone; metabolic-activation; determines susceptibility; xenobiotic-metabolism; liver-microsomes; oxidation; enzymes; mice (en)
http://linked.open.../riv/klicoveSlovo	ellipticine enzymes dna adduct formation prostaglandin-h synthase DNA adducts oxidation anticancer drug peroxidase cytochrome P450 mice metabolic-activation liver-microsomes determines susceptibility P-32-postlabelling environmental-pollutant 3-nitrobenzanthrone xenobiotic-metabolism
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[099F5ECDF8B8]
http://linked.open...i/riv/nazevZdroje	Toxicology and applied pharmacology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of targeted therapeutic drugs Study on mechanism of antineoplastic action of an anticancer drug ellipticine
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	226
http://linked.open...iv/tvurceVysledku	Hudeček, Jiří Stiborová, Marie Kotrbová, Věra Moserová, Michaela
http://linked.open...ain/vavai/riv/wos	000253002200011
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	0041-008X
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11310
is http://linked.open...avai/riv/vysledek of	Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

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