About: Subcellular Redistribution of Trimeric G-Proteins - Potential Mechanism of Desensitization of Hormone Response: Internalization, Solubilization, Down-regulation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Agonist-induced subcellular redistribution of G-protein coupled receptors (GPCR) and of trimeric guanine-nucleotide binding regulatory proteins (G-proteins) represent mechanisms of desensitization of hormone response, which have been studied in our laboratory since 1989. This review brings a short summary of these results and also presents information about related literature data covering at least small part of research carried out in this area. We have also mentioned sodium plus potassium dependent adenosine triphosphatase (Na, K-ATPase) and 3Houabain binding as useful reference standard of plasma membrane purity in the brain. Agonist-induced subcellular redistribution of G-protein coupled receptors (GPCR) and of trimeric guanine-nucleotide binding regulatory proteins (G-proteins) represent mechanisms of desensitization of hormone response, which have been studied in our laboratory since 1989. This review brings a short summary of these results and also presents information about related literature data covering at least small part of research carried out in this area. We have also mentioned sodium plus potassium dependent adenosine triphosphatase (Na, K-ATPase) and 3Houabain binding as useful reference standard of plasma membrane purity in the brain. (en)
Title	Subcellular Redistribution of Trimeric G-Proteins - Potential Mechanism of Desensitization of Hormone Response: Internalization, Solubilization, Down-regulation Subcellular Redistribution of Trimeric G-Proteins - Potential Mechanism of Desensitization of Hormone Response: Internalization, Solubilization, Down-regulation (en)
skos:prefLabel	Subcellular Redistribution of Trimeric G-Proteins - Potential Mechanism of Desensitization of Hormone Response: Internalization, Solubilization, Down-regulation Subcellular Redistribution of Trimeric G-Proteins - Potential Mechanism of Desensitization of Hormone Response: Internalization, Solubilization, Down-regulation (en)
skos:notation	RIV/00216208:11310/08:10111369!RIV12-MSM-11310___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA309/06/0121), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Svoboda, Petr Ostašov, Pavel Hejnová, Lucie Novotný, Jiří Drastichová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	398231
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/08:10111369
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	K-ATPase; Na; Desensitization; trimeric G-proteins; subcellular fractionation; brain (en)
http://linked.open.../riv/klicoveSlovo	Desensitization subcellular fractionation trimeric G-proteins K-ATPase Na brain
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[BD8433299BDE]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Neuroscience Centre Subcellular distribution of mu- and delta-opioid receptors and functional activity of trimeric G proteins after the long-term morphine stimulation.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Novotný, Jiří Rudajev, Vladimír Soukup, Tomáš Svoboda, Petr Teisinger, Jan Ostašov, Pavel Hejnová, Lucie Drastichová, Zdeňka Durchánková, Dana Bouřová, Lenka Lisý, Václav Stohr, Jiří
http://linked.open...ain/vavai/riv/wos	000262473500002
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11310
is http://linked.open...avai/riv/vysledek of	Subcellular Redistribution of Trimeric G-Proteins - Potential Mechanism of Desensitization of Hormone Response: Internalization, Solubilization, Down-regulation Subcellular Redistribution of Trimeric G-Proteins - Potential Mechanism of Desensitization of Hormone Response: Internalization, Solubilization, Down-regulation

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