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Description
| - Various types of oximes reactivate AChE and are commonly used as antidotes against organophosphates (pesticides, nerve agents). Effects both of AChE inhibitors (tacrine, 7-methoxytacrine) and oximes (pralidoxime, trimedoxime, obidoxime, methoxime, HI-6) on Complex I of electron transport chain (ETC) were examined. The enzyme activity was measured spectrophotometrically in crude mitochondrial fraction isolated from pig brain. Our results showed statistically significant Complex I inhibition by tacrine, other drugs did not affect the enzyme activity significantly.
- Various types of oximes reactivate AChE and are commonly used as antidotes against organophosphates (pesticides, nerve agents). Effects both of AChE inhibitors (tacrine, 7-methoxytacrine) and oximes (pralidoxime, trimedoxime, obidoxime, methoxime, HI-6) on Complex I of electron transport chain (ETC) were examined. The enzyme activity was measured spectrophotometrically in crude mitochondrial fraction isolated from pig brain. Our results showed statistically significant Complex I inhibition by tacrine, other drugs did not affect the enzyme activity significantly. (en)
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Title
| - In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain
- In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain (en)
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skos:prefLabel
| - In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain
- In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain (en)
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skos:notation
| - RIV/00216208:11160/11:10100203!RIV12-MSM-11160___
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GAP303/11/1907), S, Z(MSM0021620849)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11160/11:10100203
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - tacrine; oxime; NADH dehydrogenase; 7-MEOTA; electron transport chain; acetylcholinesterase (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Neuroendocrinology Letters
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Fišar, Zdeněk
- Hroudová, Jana
- Kuča, Kamil
- Korábečný, Jan
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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