About: Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	NMDA receptory jsou široce rozšířené, ligandy otevírané a napěťově závislé iontové kanály, citlivé současně na L-glutamát a glycin. NMDA receptory jsou široce rozšířené, ligandy otevírané a napěťově závislé iontové kanály, citlivé současně na L-glutamát a glycin. (cs) NMDA receptors are widely distributed, rapidly responding ligand-gated and voltage-dependent cationic channels sensitive to L-glutamate and glycine. The NMDA receptors are essential for the normal function of the excitatory glutamatergic neurotransmission. The receptor/channel complexes are highly permeable to Ca2+ and are subject to regulation by a variety of factors. Usually present as tetramers of protein subunits, NMDA receptors are formed by NR1, NR2 and/or NR3 subunits; however, all functional complexes must include NR1 subunits. The presence of NR2 and NR3 subunits and/or the nature of their spice variants may influence a range of NMDA receptor characteristics such as binding affinities for glutamate and glycine. Altered function of NMDA receptors has been linked to the etilogy of mental disease, particularly as a part of the %22glutmatergic hypothesis of schizophrenia%22. The functional changes in NMDA receptors could result from genetically determined variations in individual protein s (en)
Title	Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi (cs) Composition and function of NMDA receptor in schizophrenia: from animal models to a patient (en)
skos:prefLabel	Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi (cs) Composition and function of NMDA receptor in schizophrenia: from animal models to a patient (en)
skos:notation	RIV/00216208:11120/06:00000079!RIV07-MSM-11120___
http://linked.open.../vavai/riv/strany	7-14
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(1M0517), P(NF7626), S, Z(MZ0PCP2005)
http://linked.open...iv/cisloPeriodika	Suppl. 2
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Höschl, Cyril Šťastný, František Vrajová, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	501544
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/06:00000079
http://linked.open...riv/jazykVysledku	cze - čeština
http://linked.open.../riv/klicovaSlova	glutamate; glycine; D-serine; NMDA receptor; NR1/NR2/NR3 subunits; animal model; schizophrenia (en)
http://linked.open.../riv/klicoveSlovo	NMDA receptor glutamate D-serine glycine animal model schizophrenia NR1/NR2/NR3 subunits
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[FDC19910FF40]
http://linked.open...i/riv/nazevZdroje	Psychiatrie
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application) Levels of brain glutamate and subunit composition of glutamate receptor of NMDA type in schiziphrenia: experimantal and clinical study.
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Höschl, Cyril Šťastný, František Vrajová, Monika Tejkalová, H. Peková, S. Mareš, V. Balcar, V. J. Kozmiková, I. Jirásková, J.
http://linked.open...n/vavai/riv/zamer	Study of Sources f Psychiatric Morbidity , and Increasing the Effec-tiveness of the Preventative and Therapeutical methods in mental Health Care in the Czech Republic 2005?2011
issn	1211-7579
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi Stavba a funkce NMDA receptoru u schizofrenie: od animálních modelů k pacientovi

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