About: Identification of 1-adenine DNA adducts in workers occupationally exposed to styrene

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About: Identification of 1-adenine DNA adducts in workers occupationally exposed to styrene Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1097/00043764-200108000-00007
Description	Styrene is an extensively used industrial chemical that has been classified as a possible human carcinogen. The possible carcinogenicity may be related to the covalent DNA binding properties of styrene 7,8-oxide, a major metabolite of styrene. We have developed a sensitive and a highly specific phosphorus-32--postlabeling method for the determination of 1-styrene 7,8-oxide-adenine DNA adducts. These adducts were analyzed in white blood cells from workers exposed to styrene at mean level of 76.2 mg/m(3). Three of nine exposed workers showed adducts above the detection limit; the mean was 0.79 +/- 0.14 1-styrene 7,8-oxide-adenine DNA adducts/10(9) nucleotides. None of the 11 control cells showed adducts above the detection limit, which was 0.4 adducts/10(9) nucleotides. The results show a potential of I-adenine DNA adducts for predicting risks in the workers exposed to styrene. Styrene is an extensively used industrial chemical that has been classified as a possible human carcinogen. The possible carcinogenicity may be related to the covalent DNA binding properties of styrene 7,8-oxide, a major metabolite of styrene. We have developed a sensitive and a highly specific phosphorus-32--postlabeling method for the determination of 1-styrene 7,8-oxide-adenine DNA adducts. These adducts were analyzed in white blood cells from workers exposed to styrene at mean level of 76.2 mg/m(3). Three of nine exposed workers showed adducts above the detection limit; the mean was 0.79 +/- 0.14 1-styrene 7,8-oxide-adenine DNA adducts/10(9) nucleotides. None of the 11 control cells showed adducts above the detection limit, which was 0.4 adducts/10(9) nucleotides. The results show a potential of I-adenine DNA adducts for predicting risks in the workers exposed to styrene. (en)
Title	Identification of 1-adenine DNA adducts in workers occupationally exposed to styrene Identification of 1-adenine DNA adducts in workers occupationally exposed to styrene (en)
skos:prefLabel	Identification of 1-adenine DNA adducts in workers occupationally exposed to styrene Identification of 1-adenine DNA adducts in workers occupationally exposed to styrene (en)
skos:notation	RIV/00216208:11120/01:00003597!RIV12-GA0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA313/99/1460), Z(AV0Z5039906)
http://linked.open...iv/cisloPeriodika	82
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vodička, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	682303
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/01:00003597
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	white blood-cells; lamination workers; T-lymphocytes; oxide; persistence; carcinogen; biomarkers; adenine (en)
http://linked.open.../riv/klicoveSlovo	T-lymphocytes biomarkers persistence oxide white blood-cells adenine carcinogen lamination workers
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F7E94A90674A]
http://linked.open...i/riv/nazevZdroje	Journal of Occupational and Environmental Medicine
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of genotoxic effects and prospects to the evaluation of individual susceptibility to styrene exposure
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Vodička, Pavel
http://linked.open...ain/vavai/riv/wos	000170457500006
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	1076-2752
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1097/00043764-200108000-00007
http://localhost/t...ganizacniJednotka	11120

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