About: Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs

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About: Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.molbiolcell.org/content/11/2/497.full.pdf+html
Description	In the present study, the spatial organization of intron-containing pre-mRNAs of Epstein-Barr virus (EBV) genes relative to location of splicing factors is investigated. The intranuclear position of transcriptionally active EBV genes, as well as of nascent transcripts, is found to be random with respect to the speckled accumulations of splicing factors (SC35 domains) in Namalwa cells, arguing against the concept of the locus-specific organization of mRNA genes with respect to the speckles. Microclusters of splicing factors are, however, frequently superimposed on nascent transcript sites. The transcript environment is a dynamic structure consisting of both nascent and released transcripts, i.e., the track-like transcript environment. Both EBV sequences of the chromosome 1 homologue are usually associated with the track, are transcriptionally active, and exhibit in most cases a polar orientation. in contrast to nascent transcripts (in the form of spots), the association of a post-transcriptional pool o In the present study, the spatial organization of intron-containing pre-mRNAs of Epstein-Barr virus (EBV) genes relative to location of splicing factors is investigated. The intranuclear position of transcriptionally active EBV genes, as well as of nascent transcripts, is found to be random with respect to the speckled accumulations of splicing factors (SC35 domains) in Namalwa cells, arguing against the concept of the locus-specific organization of mRNA genes with respect to the speckles. Microclusters of splicing factors are, however, frequently superimposed on nascent transcript sites. The transcript environment is a dynamic structure consisting of both nascent and released transcripts, i.e., the track-like transcript environment. Both EBV sequences of the chromosome 1 homologue are usually associated with the track, are transcriptionally active, and exhibit in most cases a polar orientation. in contrast to nascent transcripts (in the form of spots), the association of a post-transcriptional pool o (en)
Title	Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs (en)
skos:prefLabel	Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs (en)
skos:notation	RIV/00216208:11120/00:00003754!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA302/99/0587), P(GA304/00/1481), P(VS96129), Z(AV0Z5039906)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Jirsová, Kateřina Raška, Ivan Melčák, Ivo Malinský, Jan Koberna, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	719717
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003754
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RNA-Polymerase-Ii; Epstein-Barr-Virus; C-Terminal Domain; Human Dystrophin Gene; Messenger-Rna; Nascent Transcripts; Insitu Hybridization; Integrated Copies; Infected-Cells; In-Vivo (en)
http://linked.open.../riv/klicoveSlovo	Messenger-Rna In-Vivo C-Terminal Domain Epstein-Barr-Virus Human Dystrophin Gene Infected-Cells Insitu Hybridization Integrated Copies Nascent Transcripts RNA-Polymerase-Ii
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C6021B87825A]
http://linked.open...i/riv/nazevZdroje	Molecular Biology of the Cell
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional organization of the cell nucleus Dynamic structure and function in the cell nucleus Laboratory of gene expression
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Raška, Ivan Jirsová, Kateřina Malínský, Jan Koberna, Karel Melčák, Ivo Cermanová, Štěpánka
http://linked.open...ain/vavai/riv/wos	000085478500007
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	1059-1524
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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