About: Tissue-engineered Skin in the Treatment of Vitiligo Lesions

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Vitiligo is characterized by the loss of skin pigmentation due to the destruction of melanocytes, Its treatment is usually difficult. For stable cases, melanocyte transplantation is the method of choice. A newly developed treatment with recombined human/porcine skin methodology, permitting easy handling of the graft, is described in the present work. In five vitiligo patients, autologous epidermal cells were obtained from pigmented thin skin biopsies, The cells were cultured on a dried cell-free porcine dermis by the 3T3 feeder layer technique. After 10 days melanocytes were regularly dispersed in confluent keratinocyte cultures. Upside-down delivery of epidermal cells was used. The epidermal layer was directly applied onto a dermabraded vitiligo lesion, with porcine dermis covering the lesion. Pigmentation started to be visible 4-6 weeks after grafting. After using the above described methodology, the pigmentation appeared in the range of 65-80% of the grafted area, Additional UVA irradiation enhance Vitiligo is characterized by the loss of skin pigmentation due to the destruction of melanocytes, Its treatment is usually difficult. For stable cases, melanocyte transplantation is the method of choice. A newly developed treatment with recombined human/porcine skin methodology, permitting easy handling of the graft, is described in the present work. In five vitiligo patients, autologous epidermal cells were obtained from pigmented thin skin biopsies, The cells were cultured on a dried cell-free porcine dermis by the 3T3 feeder layer technique. After 10 days melanocytes were regularly dispersed in confluent keratinocyte cultures. Upside-down delivery of epidermal cells was used. The epidermal layer was directly applied onto a dermabraded vitiligo lesion, with porcine dermis covering the lesion. Pigmentation started to be visible 4-6 weeks after grafting. After using the above described methodology, the pigmentation appeared in the range of 65-80% of the grafted area, Additional UVA irradiation enhance (en)
Title	Tissue-engineered Skin in the Treatment of Vitiligo Lesions Tissue-engineered Skin in the Treatment of Vitiligo Lesions (en)
skos:prefLabel	Tissue-engineered Skin in the Treatment of Vitiligo Lesions Tissue-engineered Skin in the Treatment of Vitiligo Lesions (en)
skos:notation	RIV/00216208:11120/00:00003132!RIV12-MZ0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IZ4368), P(NK6126), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Havlíčková, Michaela Brož, L. Veselý, Pavol Arenberger, Petr Matoušková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	729365
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/00:00003132
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	recombined human; porcine skin; upside-down grafting; melanocyte; keratinocyte; tissue culture (en)
http://linked.open.../riv/klicoveSlovo	tissue culture melanocyte porcine skin recombined human upside-down grafting keratinocyte
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[188B35E34FC9]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	FO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Comparison of healing effects of allogeneic keratinocytes c cultured on xenodermis and aquagel on burns and donor sites The recombinant skin in the basic and clinical research
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Arenberger, Petr Matoušková, Eva Brož, Ludomír Havlíčková, Blanka Veselý, Pavol
http://linked.open...ain/vavai/riv/wos	000088667600006
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0015-5500
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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