About: How does fingolimod (gilenya(R)) fit in the treatment algorithm for highly active relapsing-remitting multiple sclerosis?     Goto   Sponge   NotDistinct   Permalink

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Description
  • Multiple sclerosis (MS) is a neurological disorder characterized by inflammatory demyelination and neurodegeneration in the central nervous system. Until recently, disease-modifying treatment was based on agents requiring parenteral delivery, thus limiting long-term compliance. Basic treatments such as beta-interferon provide only moderate efficacy, and although therapies for second-line treatment and highly active MS are more effective, they are associated with potentially severe side effects. Fingolimod (Gilenya(R)) is the first oral treatment of MS and has recently been approved as single disease-modifying therapy in highly active relapsing-remitting multiple sclerosis (RRMS) for adult patients with high disease activity despite basic treatment (beta-interferon) and for treatment-naïve patients with rapidly evolving severe RRMS. At a scientific meeting that took place in Vienna on November 18th, 2011, experts from ten Central and Eastern European countries discussed the clinical benefits and potential risks of fingolimod for MS, suggested how the new therapy fits within the current treatment algorithm and provided expert opinion for the selection and management of patients.
  • Multiple sclerosis (MS) is a neurological disorder characterized by inflammatory demyelination and neurodegeneration in the central nervous system. Until recently, disease-modifying treatment was based on agents requiring parenteral delivery, thus limiting long-term compliance. Basic treatments such as beta-interferon provide only moderate efficacy, and although therapies for second-line treatment and highly active MS are more effective, they are associated with potentially severe side effects. Fingolimod (Gilenya(R)) is the first oral treatment of MS and has recently been approved as single disease-modifying therapy in highly active relapsing-remitting multiple sclerosis (RRMS) for adult patients with high disease activity despite basic treatment (beta-interferon) and for treatment-naïve patients with rapidly evolving severe RRMS. At a scientific meeting that took place in Vienna on November 18th, 2011, experts from ten Central and Eastern European countries discussed the clinical benefits and potential risks of fingolimod for MS, suggested how the new therapy fits within the current treatment algorithm and provided expert opinion for the selection and management of patients. (en)
Title
  • How does fingolimod (gilenya(R)) fit in the treatment algorithm for highly active relapsing-remitting multiple sclerosis?
  • How does fingolimod (gilenya(R)) fit in the treatment algorithm for highly active relapsing-remitting multiple sclerosis? (en)
skos:prefLabel
  • How does fingolimod (gilenya(R)) fit in the treatment algorithm for highly active relapsing-remitting multiple sclerosis?
  • How does fingolimod (gilenya(R)) fit in the treatment algorithm for highly active relapsing-remitting multiple sclerosis? (en)
skos:notation
  • RIV/00216208:11110/13:10191137!RIV14-MSM-11110___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika
  • May
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 78128
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/13:10191137
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • treatment; multiple sclerosis; fingolimod; expert opinion; Algorithm (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [57EE01DAC379]
http://linked.open...i/riv/nazevZdroje
  • Frontiers in Neurology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 4
http://linked.open...iv/tvurceVysledku
  • Havrdová, Eva
  • Taláb, Radomír
  • Fazekas, Franz
  • Bajenaru, Ovidiu
  • Berger, Thomas
  • Fabjan, T. H.
  • Jakab, Gábor
  • Jazbec, Saša Šega
  • Kobys, Tetiana
  • Komoly, Samuel
  • Kraus, Jorg
  • Kurča, Egon
  • Kyriakides, Theodoros
  • Ledinek, AH
  • Lisý, Lubomír
  • Milanov, Ivan
  • Moskovko, Sergii
  • Nehrych, Tetyana
  • Panayiotou, Panayiotis
  • Sokolova, Larysa
  • Traykov, Latchezar
  • Turčáni, Peter
  • Vass, Karl
  • Vella, Norbert
  • Voloshyna, Nataliya
http://linked.open...n/vavai/riv/zamer
issn
  • 1664-2295
number of pages
http://bibframe.org/vocab/doi
  • 10.3389/fneur.2013.00010
http://localhost/t...ganizacniJednotka
  • 11110
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