About: Prenatal adaptations to overload

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/978-1-4614-5203-4_3
Description	Like every muscle in the body, the heart adapts its structure and mass to functional requirements, which are primarily determined by loading conditions. These can be classified as pressure loading (increased afterload, as in hypertension or banding of an artery), or volume loading (preload, which could be increased by creating an arterio-venous shunt, valve regurgitation, or shifting the blood streams). While numerous models exist for modifying the loading conditions postnatally, this chapter focuses on those few created in the developing heart, chiefly during prenatal development. As the reactions of the early postnatal heart are somewhat similar to the response of the fetal one, discussion of early postnatal models is also included. Principal findings from these studies are considered in the light of clinical scenarios of abnormal loading in congenital heart malformations and their optimal surgical management. Like every muscle in the body, the heart adapts its structure and mass to functional requirements, which are primarily determined by loading conditions. These can be classified as pressure loading (increased afterload, as in hypertension or banding of an artery), or volume loading (preload, which could be increased by creating an arterio-venous shunt, valve regurgitation, or shifting the blood streams). While numerous models exist for modifying the loading conditions postnatally, this chapter focuses on those few created in the developing heart, chiefly during prenatal development. As the reactions of the early postnatal heart are somewhat similar to the response of the fetal one, discussion of early postnatal models is also included. Principal findings from these studies are considered in the light of clinical scenarios of abnormal loading in congenital heart malformations and their optimal surgical management. (en)
Title	Prenatal adaptations to overload Prenatal adaptations to overload (en)
skos:prefLabel	Prenatal adaptations to overload Prenatal adaptations to overload (en)
skos:notation	RIV/00216208:11110/13:00011383!RIV14-MSM-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA304/08/0615), P(GAP302/11/1308), Z(AV0Z50110509), Z(MSM0021620806)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Sedmera, David Peševski, Živorad
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	98919
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/13:00011383
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prenatal myocardium; left atrial ligation; conotruncal banding; pulmonary artery banding; aortic banding; hypertrophy; hyperplasia; fetal sheep; chick embryo (en)
http://linked.open.../riv/klicoveSlovo	hypertrophy chick embryo aortic banding conotruncal banding fetal sheep left atrial ligation prenatal myocardium pulmonary artery banding hyperplasia
http://linked.open...ontrolniKodProRIV	[540FDC608122]
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...vEdiceCisloSvazku	Advances in Biochemistry in Health and Disease, Vol 4
http://linked.open...i/riv/nazevZdroje	Cardiac adaptations. Molecular mechanisms
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	465 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of cardiac conduction system development Epigenetic factors in myocardial morphogenesis
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Sedmera, David Peševski, Živorad
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
number of pages	17 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/978-1-4614-5203-4_3
http://purl.org/ne...btex#hasPublisher	Springer-Verlag
https://schema.org/isbn	978-1-4614-5202-7
http://localhost/t...ganizacniJednotka	11110

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