About: Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization.

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About: Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1267/ahc.11014
Description	Galectins are a family of carbohydrate-binding proteins that modulate inflammation and immunity. This functional versatility prompted us to perform a histochemical study of their occurrence during wound healing. In this study antibodies against keratins-10 and -14, wide-spectrum cytokeratin, vimentin, fibronectin, and galectins-1, -2, and -3 were applied to frozen sections of skin specimens two, seven, and twenty-one days after wounding. The presence of binding sites for galectins-1, -2, -3, and -7 was determined using labeled proteins as probes. Our study detected a series of alterations in galectin parameters during different phases of wound healing. Presence of galectin-1 increased during the early phase of healing, whereas galectin-3 rapidly decreased in newly formed granulation tissue. In addition, nuclear reactivity of epidermal cells for galectin-2 occurred seven days post-trauma. The dynamic regulation of galectins during epithelization intimates a role of these proteins in wound healing. Galectins are a family of carbohydrate-binding proteins that modulate inflammation and immunity. This functional versatility prompted us to perform a histochemical study of their occurrence during wound healing. In this study antibodies against keratins-10 and -14, wide-spectrum cytokeratin, vimentin, fibronectin, and galectins-1, -2, and -3 were applied to frozen sections of skin specimens two, seven, and twenty-one days after wounding. The presence of binding sites for galectins-1, -2, -3, and -7 was determined using labeled proteins as probes. Our study detected a series of alterations in galectin parameters during different phases of wound healing. Presence of galectin-1 increased during the early phase of healing, whereas galectin-3 rapidly decreased in newly formed granulation tissue. In addition, nuclear reactivity of epidermal cells for galectin-2 occurred seven days post-trauma. The dynamic regulation of galectins during epithelization intimates a role of these proteins in wound healing. (en)
Title	Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization. Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization. (en)
skos:prefLabel	Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization. Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization. (en)
skos:notation	RIV/00216208:11110/11:8942!RIV12-MSM-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Smetana, Karel Gál, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	218440
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/11:8942
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	differentiation; lectin; migration; peoliferation; repair (en)
http://linked.open.../riv/klicoveSlovo	peoliferation lectin migration repair differentiation
http://linked.open...odStatuVydavatele	JP - Japonsko
http://linked.open...ontrolniKodProRIV	[4AA2E083B1AD]
http://linked.open...i/riv/nazevZdroje	Acta Histochemica et Cytochemica
http://linked.open...in/vavai/riv/obor	FO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	André, Sabine Gabius, Hans-Joachim Kaltner, Herbert Smetana, Karel Kováč, Ivan Gál, Peter Jakubčo, Ján Kostelníková, Martina Sabol, František Vasilenko, Tomáš
http://linked.open...ain/vavai/riv/wos	000298881100001
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	0044-5991
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11110
is http://linked.open...avai/riv/vysledek of	Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization. Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization.

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