About: Cadaveric bone marrow as potential source of hematopoietic stem cells for transplantation

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234361/pdf/chim0203_0086.pdf
Description	Every year, bone marrow transplantation saves many lives worldwide. Unfortunately, a suitable donor is not always available. Since organs are routinely harvested from cadaveric organ donors, we decided to assess such a possibility for bone marrow. We analyzed the functional properties and phenotypic markers of murine hematopoietic stem and progenitor cells (HSPC) from cadaveric bone marrow and during storage in vitro in a suspension. It was demonstrated that HSPC exposed to a warm or cold ischemia in intact femur did not lose their phenotype and maintained their repopulating ability for two to twelve hours depending on the temperature. Additionally, fresh bone marrow remained fully viable in cell suspension for two days or four days at 37 C or 4 C, respectively. Based on these findings, cadaveric bone marrow could be considered as an alternative source of hematopoietic stem cells for transplantation. Every year, bone marrow transplantation saves many lives worldwide. Unfortunately, a suitable donor is not always available. Since organs are routinely harvested from cadaveric organ donors, we decided to assess such a possibility for bone marrow. We analyzed the functional properties and phenotypic markers of murine hematopoietic stem and progenitor cells (HSPC) from cadaveric bone marrow and during storage in vitro in a suspension. It was demonstrated that HSPC exposed to a warm or cold ischemia in intact femur did not lose their phenotype and maintained their repopulating ability for two to twelve hours depending on the temperature. Additionally, fresh bone marrow remained fully viable in cell suspension for two days or four days at 37 C or 4 C, respectively. Based on these findings, cadaveric bone marrow could be considered as an alternative source of hematopoietic stem cells for transplantation. (en)
Title	Cadaveric bone marrow as potential source of hematopoietic stem cells for transplantation Cadaveric bone marrow as potential source of hematopoietic stem cells for transplantation (en)
skos:prefLabel	Cadaveric bone marrow as potential source of hematopoietic stem cells for transplantation Cadaveric bone marrow as potential source of hematopoietic stem cells for transplantation (en)
skos:notation	RIV/00216208:11110/11:11304!RIV12-MSM-11110___
http://linked.open...avai/predkladatel	1. lékařská fakulta
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(LC06044), S, Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Nečas, Emanuel Michalová, Jana Forgáčová, Katarína Savvulidi, Filipp Geirgievich Šefc, Luděk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	188991
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/11:11304
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cadaveric bone marrow; mouse; transplantation; ischemia; hematopoietic stem cells (en)
http://linked.open.../riv/klicoveSlovo	ischemia transplantation cadaveric bone marrow hematopoietic stem cells mouse
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B2CFAB9E57DF]
http://linked.open...i/riv/nazevZdroje	Chimerism
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Experimental Hematology
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Forgáčová, Katarína Michalová, Jana Nečas, Emanuel Savvulidi, Filipp Geirgievich Šefc, Luděk
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	1938-1956
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	11110
is http://linked.open...avai/riv/vysledek of	Cadaveric bone marrow as potential source of hematopoietic stem cells for transplantation Cadaveric bone marrow as potential source of hematopoietic stem cells for transplantation

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