About: Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Insufficient function of the thyroid gland can cause low concentrations of thyroid gland hormones which are necessary for the proper development of the foetus brain, especially during the beginning of pregnancy. We determined the reference interval for TSH in the first trimester of pregnancy and the decision point for anti-TPO antibodies’ positivity. We tested 5520 women from the central part of the Czech Republic during the first trimester of pregnancy for serum TSH, anti-TPO and FT4 by chemiluminometric immunoanalysis on an ADVIA Centaur system (Siemens). The reference interval for TSH was determined to be 0.06–3.67 mU/l. The suppression of TSH was found in 2.93% of the women; a raised concentration of TSH had been found in 4.48% of the women. For anti-TPO, the cut-off was established at 143 kU/l; 11.2% of the pregnant women were found to be anti-TPO positive. Insufficient function of the thyroid gland can cause low concentrations of thyroid gland hormones which are necessary for the proper development of the foetus brain, especially during the beginning of pregnancy. We determined the reference interval for TSH in the first trimester of pregnancy and the decision point for anti-TPO antibodies’ positivity. We tested 5520 women from the central part of the Czech Republic during the first trimester of pregnancy for serum TSH, anti-TPO and FT4 by chemiluminometric immunoanalysis on an ADVIA Centaur system (Siemens). The reference interval for TSH was determined to be 0.06–3.67 mU/l. The suppression of TSH was found in 2.93% of the women; a raised concentration of TSH had been found in 4.48% of the women. For anti-TPO, the cut-off was established at 143 kU/l; 11.2% of the pregnant women were found to be anti-TPO positive. (en)
Title	Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy (en)
skos:prefLabel	Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy (en)
skos:notation	RIV/00216208:11110/09:4660!RIV10-MSM-11110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620807)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Límanová, Zdeňka Springer, Drahomíra Zima, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 1. lékařská fakulta
http://linked.open...dnocenehoVysledku	338494
http://linked.open...ai/riv/idVysledku	RIV/00216208:11110/09:4660
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	thyroid dysfunction; pregnancy; reference interval; TSH; FT4; anti-TPO (en)
http://linked.open.../riv/klicoveSlovo	pregnancy thyroid dysfunction FT4 TSH reference interval anti-TPO
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8E82979A4F2F]
http://linked.open...i/riv/nazevZdroje	European Journal of Endocrinology
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	160
http://linked.open...iv/tvurceVysledku	Zima, Tomáš Límanová, Zdeňka Springer, Drahomíra
http://linked.open...ain/vavai/riv/wos	000272934500010
http://linked.open...n/vavai/riv/zamer	Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění
issn	0804-4643
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11110
is http://linked.open...avai/riv/vysledek of	Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy

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