About: Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2

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About: Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0304383513000773
Description	The pro-metasta tic protein anterior gradient- 2 (AGR2) was previously demonstrated as a predictive factor of poor response to tamoxifen treatment . In this study we aimed to delineate the key signalling pathway that may contribute to regulation of AGR2 protein induction in order to identify novel targets to overcome tamoxifen resistance in tumour cells. Together, our data identify PDPK1-AKT as a pro-oncogenic signalling pathway that triggers AGR2 protein induction in response to tamoxifen and suggest that AKT inhibitors could be used as part of a therapeutic strategy to treat tamoxifen resistant, AGR2 overexpressing cancers. The pro-metasta tic protein anterior gradient- 2 (AGR2) was previously demonstrated as a predictive factor of poor response to tamoxifen treatment . In this study we aimed to delineate the key signalling pathway that may contribute to regulation of AGR2 protein induction in order to identify novel targets to overcome tamoxifen resistance in tumour cells. Together, our data identify PDPK1-AKT as a pro-oncogenic signalling pathway that triggers AGR2 protein induction in response to tamoxifen and suggest that AKT inhibitors could be used as part of a therapeutic strategy to treat tamoxifen resistant, AGR2 overexpressing cancers. (en)
Title	Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2 Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2 (en)
skos:prefLabel	Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2 Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2 (en)
skos:notation	RIV/00209805:_____/13:#0000407!RIV14-GA0-00209805
http://linked.open...avai/predkladatel	Masarykův onkologický ústav
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0101), P(GAP301/10/1615), P(LM2010004), P(NT13794)
http://linked.open...iv/cisloPeriodika	27
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hrstka, Roman Brychtová, Veronika Vojtěšek, Bořivoj Fabian, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	78657
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/13:#0000407
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	breast cancer; AGR2; AKT; PDPK1; tamoxifen (en)
http://linked.open.../riv/klicoveSlovo	AGR2 breast cancer AKT PDPK1 tamoxifen
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[E7F503CBDF0C]
http://linked.open...i/riv/nazevZdroje	Cancer Letters
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Rodina proteinů AGR2: úloha v biologii nádorové buňky BBMRI_CZ in the building of the Czech part of a large distributed research infrastructure of pan-European importance: the creation and operation of the network of banks of biological material for biomedical research Regional Centre for Applied Molecular Oncology (RECAMO) The analysis of chaperone system and identification of new biomarkers associated with gynecological malignancies
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	333
http://linked.open...iv/tvurceVysledku	Brychtová, Veronika Hrstka, Roman Vojtěšek, Bořivoj Fabian, Pavel
http://linked.open...ain/vavai/riv/wos	000318838700007
issn	0304-3835
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.canlet.2013.01.034

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