About: Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	STAT 1 levels and inducibility of its activated phosphoforms were detected by Western analysis using specific polyclonal and monoclonal antibodies. The study demonstrates STAT 1 functional abnormalities in melanoma cells. On the basis of detail analyses of patient melanoma cells with respect to the inducibility of STAT 1 phosphorylation by IFNs, four categories of patients could be distinguished: a) activation on both S 727 and Y 701, b) not inducible response, c) activation on Y 701 but not on S 727, d) heterogeneous response. STAT 1 levels and inducibility of its activated phosphoforms were detected by Western analysis using specific polyclonal and monoclonal antibodies. The study demonstrates STAT 1 functional abnormalities in melanoma cells. On the basis of detail analyses of patient melanoma cells with respect to the inducibility of STAT 1 phosphorylation by IFNs, four categories of patients could be distinguished: a) activation on both S 727 and Y 701, b) not inducible response, c) activation on Y 701 but not on S 727, d) heterogeneous response. (en)
Title	Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation (en)
skos:prefLabel	Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation (en)
skos:notation	RIV/00209805:_____/03:00008216!RIV/2004/GA0/L26004/N
http://linked.open.../vavai/riv/strany	335; 340
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA301/00/0564), P(NC7139)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Kovařík, Jan Boudný, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	614186
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/03:00008216
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	STAT 1;malignant melanoma;signal transduction;interferons (en)
http://linked.open.../riv/klicoveSlovo	STAT 1 signal transduction interferons malignant melanoma
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[EF46749A0317]
http://linked.open...i/riv/nazevZdroje	International journal of molecular medicine
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The role and abnormalities of STAT1 in mediating the immunological and antiproliferative effects of Interferon-alpha in malignant melanoma The study of molecular defects of cancer cell in the transduction pathways of interferon signals mediated by STAT 1/SOCS 3 proteins and their significance for the prediction of tumor sensitivity to interferon therapy.
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Boudný, Vladimír Kovařík, Jan
issn	1107-3756
number of pages	6 (xsd:int)

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