About: Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using immunoprecipitation and Western blots performed on lysates made of melanoma cells derived from patients with clinical stage II/III and employing specific anti-STAT 1 PS 727/PY 701 immunoprobes, we show that STAT 1 activation response induced by IFN-alfa/-gamma is significantly impaired. In average, three quarters of patients were lacking phosphorylation at S 727. STAT 1 PY 701 was not inducible by IFN-alfa in 63% and by IFN-gamma in 34% of samples However, these STAT 1 activation defects showed no correlation with the disease outcome and immunotherapy response as indicated by progression-free survival profiles in patients treated with IFN-alfa2b. Using immunoprecipitation and Western blots performed on lysates made of melanoma cells derived from patients with clinical stage II/III and employing specific anti-STAT 1 PS 727/PY 701 immunoprobes, we show that STAT 1 activation response induced by IFN-alfa/-gamma is significantly impaired. In average, three quarters of patients were lacking phosphorylation at S 727. STAT 1 PY 701 was not inducible by IFN-alfa in 63% and by IFN-gamma in 34% of samples However, these STAT 1 activation defects showed no correlation with the disease outcome and immunotherapy response as indicated by progression-free survival profiles in patients treated with IFN-alfa2b. (en)
Title	Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients (en)
skos:prefLabel	Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients (en)
skos:notation	RIV/00209805:_____/03:00008209!RIV/2004/GA0/L26004/N
http://linked.open.../vavai/riv/strany	142; 146
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/00/0564), P(NC7139), Z(MZ00020980501)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Kovařík, Jan Boudný, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	610906
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/03:00008209
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	STAT 1;malignant melanoma;signal transduction;interferons (en)
http://linked.open.../riv/klicoveSlovo	STAT 1 signal transduction interferons malignant melanoma
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[9C1073143088]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The role and abnormalities of STAT1 in mediating the immunological and antiproliferative effects of Interferon-alpha in malignant melanoma The study of molecular defects of cancer cell in the transduction pathways of interferon signals mediated by STAT 1/SOCS 3 proteins and their significance for the prediction of tumor sensitivity to interferon therapy.
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Boudný, Vladimír Kovařík, Jan
http://linked.open...n/vavai/riv/zamer	Biologické, genetické a epidemiologické aspekty malignit a optimalizace diagnosticko-léčebných postupů
issn	0015-5500
number of pages	5 (xsd:int)

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