About: Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation

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About: Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The objectives of our study were to analyse the frequency and functional status of HIV-specific CD8+ T cells and the expression of non-specific activation markers on CD8+ T cells in HIV+ patients. We examined 28 HIV+ patients, including 13 patients not receiving therapy complex antiretroviral therapy (cART) using ELISpot assay and flow cytometry with intracellular and MHC tetramer staining. The results suggested that the alterations of HIV-specific immunity are not influenced by the therapy of HIV infection; whereas, the non-specific chronic immune activation is down-regulated by cART. The objectives of our study were to analyse the frequency and functional status of HIV-specific CD8+ T cells and the expression of non-specific activation markers on CD8+ T cells in HIV+ patients. We examined 28 HIV+ patients, including 13 patients not receiving therapy complex antiretroviral therapy (cART) using ELISpot assay and flow cytometry with intracellular and MHC tetramer staining. The results suggested that the alterations of HIV-specific immunity are not influenced by the therapy of HIV infection; whereas, the non-specific chronic immune activation is down-regulated by cART. (en)
Title	Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation (en)
skos:prefLabel	Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation Antiretroviral treatment of HIV infection does not influence HIV-specific immunity but has an impact on Non-specific immune activation (en)
skos:notation	RIV/00064211:_____/11:#0000165!RIV14-MZ0-00064211
http://linked.open...avai/predkladatel	Fakultní nemocnice s poliklinikou na Bulovce
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GD310/05/H533), S, Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Beran, Ondřej Rozsypal, Hanuš Holub, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Nemocnice Na Bulovce
http://linked.open...dnocenehoVysledku	186501
http://linked.open...ai/riv/idVysledku	RIV/00064211:_____/11:#0000165
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Antiretroviral therapy; CD38; HIV infection; HIV-specific CD8+ T cells; HLA-DR; Multifunctional CD8+ T cells (en)
http://linked.open.../riv/klicoveSlovo	Antiretroviral therapy CD38 HIV infection HIV-specific CD8+ T cells HLA-DR Multifunctional CD8+ T cells
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[10D040EC414C]
http://linked.open...i/riv/nazevZdroje	Current HIV Research
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of infectious diseases and their causative agents
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Bartovská, Zofia Beran, Ondřej Holub, Michal Rozsypal, Hanuš
http://linked.open...ain/vavai/riv/wos	000299645400003
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	1570-162X
number of pages	7 (xsd:int)

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