About: Cortisol kinetics in cerebrospinal fluid during bacterial meningitis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bacterial meningitis (BM) remains an infectious disease with a significant morbidity and mortality. The aim of this study was to describe the kinetics of cerebrospinal fluid (CSF) cortisol levels during BM and to assess its relationship to disease severity and etiology. A total of 55 patients with BM were enrolled in the study. Elevated CSF cortisol upon admission and its rapid decrease after starting therapy were associated with increased BM severity as assessed by the Acute Physiology and Chronic Health Evaluation II score, the Sequential Organ Failure Assessment score, Glasgow Coma Scale score and the Glasgow Outcome Scale score. The comparison of CSF cortisol according to BM etiology revealed a trend toward higher concentrations in meningitis caused by Streptococcus pneumoniae compared to Neisseria meningitidis. Our results demonstrate that the initially elevated CSF cortisol concentrations decrease rapidly after administration of BM therapy (i.e. antibiotics and dexamethasone). Bacterial meningitis (BM) remains an infectious disease with a significant morbidity and mortality. The aim of this study was to describe the kinetics of cerebrospinal fluid (CSF) cortisol levels during BM and to assess its relationship to disease severity and etiology. A total of 55 patients with BM were enrolled in the study. Elevated CSF cortisol upon admission and its rapid decrease after starting therapy were associated with increased BM severity as assessed by the Acute Physiology and Chronic Health Evaluation II score, the Sequential Organ Failure Assessment score, Glasgow Coma Scale score and the Glasgow Outcome Scale score. The comparison of CSF cortisol according to BM etiology revealed a trend toward higher concentrations in meningitis caused by Streptococcus pneumoniae compared to Neisseria meningitidis. Our results demonstrate that the initially elevated CSF cortisol concentrations decrease rapidly after administration of BM therapy (i.e. antibiotics and dexamethasone). (en)
Title	Cortisol kinetics in cerebrospinal fluid during bacterial meningitis Cortisol kinetics in cerebrospinal fluid during bacterial meningitis (en)
skos:prefLabel	Cortisol kinetics in cerebrospinal fluid during bacterial meningitis Cortisol kinetics in cerebrospinal fluid during bacterial meningitis (en)
skos:notation	RIV/00064211:_____/11:#0000160!RIV14-MZ0-00064211
http://linked.open...avai/predkladatel	Fakultní nemocnice s poliklinikou na Bulovce
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NT11390), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Beran, Ondřej Holub, Michal Džupová, Olga
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Nemocnice Na Bulovce
http://linked.open...dnocenehoVysledku	192086
http://linked.open...ai/riv/idVysledku	RIV/00064211:_____/11:#0000160
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Bacterial meningitis; Cerebrospinal fluid; Cortisol; Neisseria meningitidis; Streptococcus pneumoni (en)
http://linked.open.../riv/klicoveSlovo	Bacterial meningitis Cerebrospinal fluid Cortisol Neisseria meningitidis Streptococcus pneumoni
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B339B14B1403]
http://linked.open...i/riv/nazevZdroje	Journal of Clinical Neuroscience
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New biomarkers for a rapid detection of nosocomial infection in intensive care
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Beran, Ondřej Džupová, Olga Holub, Michal
http://linked.open...ain/vavai/riv/wos	000292066700039
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	0967-5868
number of pages	2 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jocn.2010.12.020

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