About: Vertebrate metallothioneins as target molecules for analytical techniques

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Metallothioneins (MTs) are a family of ubiquitous, biologically interesting proteins that have been isolated and studied in a wide variety of organisms. Due to the property of MTs being metal-inducible and their high affinity to metal ions, homeostasis of heavy-metal levels is probably their most important biological function. MTs are also involved in other important biochemical pathways, including scavenging of reactive oxygen species, activation of transcription factors and participation in carcinogenesis. Analytical methods for detection of MT are based on: a) detection of bound metal ion; b) detection of free -SH groups; c) protein mobility in electrical field; and, d) interaction with different types of sorbent. Metallothioneins (MTs) are a family of ubiquitous, biologically interesting proteins that have been isolated and studied in a wide variety of organisms. Due to the property of MTs being metal-inducible and their high affinity to metal ions, homeostasis of heavy-metal levels is probably their most important biological function. MTs are also involved in other important biochemical pathways, including scavenging of reactive oxygen species, activation of transcription factors and participation in carcinogenesis. Analytical methods for detection of MT are based on: a) detection of bound metal ion; b) detection of free -SH groups; c) protein mobility in electrical field; and, d) interaction with different types of sorbent. (en)
Title	Vertebrate metallothioneins as target molecules for analytical techniques Vertebrate metallothioneins as target molecules for analytical techniques (en)
skos:prefLabel	Vertebrate metallothioneins as target molecules for analytical techniques Vertebrate metallothioneins as target molecules for analytical techniques (en)
skos:notation	RIV/00064203:_____/10:6234!RIV11-MZ0-00064203
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(IAA401990701), Z(MSM0021620808), Z(MSM0021622412)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Eckschlager, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	295569
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/10:6234
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Capillary electrophoresis; Electrochemistry; ELISA; Gel electrophoresis; High-performance liquid chromatography; Immunochemistry; Metallothionein; Saturation assay; Spectrometry; Voltammetry; linked-immunosorbent-assay; plasma-mass spectrometry; performance liquid-chromatography; capillary-zone-electrophoresis; bioinorganic speciation analysis; transfer stripping technique; rabbit liver apothioneins; mercury saturation assay; tumor-cell lines; hplc-icp-ms (en)
http://linked.open.../riv/klicoveSlovo	Capillary electrophoresis Electrochemistry Gel electrophoresis Immunochemistry Metallothionein performance liquid-chromatography plasma-mass spectrometry ELISA High-performance liquid chromatography linked-immunosorbent-assay Spectrometry Voltammetry transfer stripping technique Saturation assay bioinorganic speciation analysis capillary-zone-electrophoresis hplc-icp-ms mercury saturation assay rabbit liver apothioneins tumor-cell lines
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D9F10A0B1DE9]
http://linked.open...i/riv/nazevZdroje	Trac-Trends in Analytical Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Adam, V. Eckschlager, Tomáš Kizek, R. Stiborova, M. Fabrik, I. Trnková, L.
http://linked.open...ain/vavai/riv/wos	000277698300014
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
issn	0165-9936
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Vertebrate metallothioneins as target molecules for analytical techniques Vertebrate metallothioneins as target molecules for analytical techniques Vertebrate metallothioneins as target molecules for analytical techniques

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