About: New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting

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About: New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/18304673
Description	Various conjugates of anticancer drug doxorubicin covalently bound by the hydrolytically degradable hydrazone bond to the drug carrier based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesised. Structure of the conjugates differed in the type and the content of hydrophobic substituent (dodecyl, oleic acid and cholesterol moieties) introduced into the polymer structure. Various conjugates of anticancer drug doxorubicin covalently bound by the hydrolytically degradable hydrazone bond to the drug carrier based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesised. Structure of the conjugates differed in the type and the content of hydrophobic substituent (dodecyl, oleic acid and cholesterol moieties) introduced into the polymer structure. (en)
Title	New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting (en)
skos:prefLabel	New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting (en)
skos:notation	RIV/00064203:_____/08:6929!RIV12-MZ0-00064203
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(FI-IM2/111), P(KAN200200651), Z(AV0Z40500505), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Bouček, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice v Motole
http://linked.open...dnocenehoVysledku	382563
http://linked.open...ai/riv/idVysledku	RIV/00064203:_____/08:6929
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HPMA copolymers; drug carriers; doxorubicin (en)
http://linked.open.../riv/klicoveSlovo	drug carriers doxorubicin HPMA copolymers
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[549C38BF3B6A]
http://linked.open...i/riv/nazevZdroje	Journal of Controlled Release
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanoparticulate and supramolecular systems for targeted drug delivery *Preclinical trials of polymer bound cytostatic and synthesis scale-up transfer from laboratory conditions.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	127
http://linked.open...iv/tvurceVysledku	Bouček, Jan Ulbrich, K. Chytil, P. Etrych, T. Konak, C. Mrkvan, T. Rihova, B. Sirova, M.
http://linked.open...ain/vavai/riv/wos	000255892600003
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Microorganisms in Research and Biotechnology
issn	0168-3659
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting

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