About: A FTO variant and risk of acute coronary syndrome

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The Fro gene plays an important role in the determination of body weight and BMI and it has been suspected of being associated with all-case mortality. Methods: We have analyzed the FTO rs17817449 variant in consecutive 1092 male patients with acute coronary syndrome (ACS) and in 1191 randomly selected Caucasian individuals (population controls). Results: The FTO variant was significantly associated with BMI both in controls (P<0.02) and ACS patients (P<0.01). In both groups, BMI was highest in GC homozygotes and lowest in IT homozygotes. There was a significant difference between the ACS patients and controls in the frequency of the FTO genotype GC (21.4% vs. 15.9%, P<0.005). FTO GG homozygotes had a significantly increased risk of ACS, compared with TT homozygotes which was independent of age and BMI (odds ratio 1.49, 95% confidence interval 1.16-1.93). The odds ratio of ACS patients for the GC genotype remained significant even after the exclusion of diabetics (100 controls and 339 ACS patients), with OR 1.32 (95% Cl 1.01-1.72). Conclusions: This study provides an evidence of an association between the FTO variant and risk of ACS in Caucasian males. The Fro gene plays an important role in the determination of body weight and BMI and it has been suspected of being associated with all-case mortality. Methods: We have analyzed the FTO rs17817449 variant in consecutive 1092 male patients with acute coronary syndrome (ACS) and in 1191 randomly selected Caucasian individuals (population controls). Results: The FTO variant was significantly associated with BMI both in controls (P<0.02) and ACS patients (P<0.01). In both groups, BMI was highest in GC homozygotes and lowest in IT homozygotes. There was a significant difference between the ACS patients and controls in the frequency of the FTO genotype GC (21.4% vs. 15.9%, P<0.005). FTO GG homozygotes had a significantly increased risk of ACS, compared with TT homozygotes which was independent of age and BMI (odds ratio 1.49, 95% confidence interval 1.16-1.93). The odds ratio of ACS patients for the GC genotype remained significant even after the exclusion of diabetics (100 controls and 339 ACS patients), with OR 1.32 (95% Cl 1.01-1.72). Conclusions: This study provides an evidence of an association between the FTO variant and risk of ACS in Caucasian males. (en)
Title	A FTO variant and risk of acute coronary syndrome A FTO variant and risk of acute coronary syndrome (en)
skos:prefLabel	A FTO variant and risk of acute coronary syndrome A FTO variant and risk of acute coronary syndrome (en)
skos:notation	RIV/00064173:_____/10:00002649!RIV13-MZ0-00064173
http://linked.open...avai/riv/aktivita	I P V
http://linked.open...avai/riv/aktivity	I, P(NR9093), V
http://linked.open...iv/cisloPeriodika	15-16
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Hrabáková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Královské Vinohrady
http://linked.open...dnocenehoVysledku	244633
http://linked.open...ai/riv/idVysledku	RIV/00064173:_____/10:00002649
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Body mass index; Polymorphism; FTO; Acute coronary syndrome (en)
http://linked.open.../riv/klicoveSlovo	FTO Body mass index Polymorphism Acute coronary syndrome
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[F8DAF528030F]
http://linked.open...i/riv/nazevZdroje	Clinica Chimica Acta
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetical determination of acute coronary syndromes - population study
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	411
http://linked.open...iv/tvurceVysledku	Hrabáková, Hana Hubáček, Jaroslav A
http://linked.open...ain/vavai/riv/wos	000279299100011
issn	0009-8981
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.cca.2010.03.037
is http://linked.open...avai/riv/vysledek of	A FTO variant and risk of acute coronary syndrome

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