About: Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • p53 is implemented in many processes controlling cell fate. Recently it has been reported that besides post-translational modifications and regulation of protein-protein interactions, the activity of p53 is also substantially controlled at transcriptional level. In 109 out of 127 (86%) patients with chronic lymphocytic leukemia (CLL) we have identified a novel p53 splicing variant, lacking the whole coding sequence of exon 6. This splicing p53 isoform (%22delta ex6%22) is devoid of transactivational activity and is differentially expressed in CLL patients as compared to healthy controls. The overexpression of %22delta ex6%22 p53 variant in CLL patients supports the recent evidence on dysregulation of p53 splicing pattern in malignancies
  • p53 is implemented in many processes controlling cell fate. Recently it has been reported that besides post-translational modifications and regulation of protein-protein interactions, the activity of p53 is also substantially controlled at transcriptional level. In 109 out of 127 (86%) patients with chronic lymphocytic leukemia (CLL) we have identified a novel p53 splicing variant, lacking the whole coding sequence of exon 6. This splicing p53 isoform (%22delta ex6%22) is devoid of transactivational activity and is differentially expressed in CLL patients as compared to healthy controls. The overexpression of %22delta ex6%22 p53 variant in CLL patients supports the recent evidence on dysregulation of p53 splicing pattern in malignancies (en)
Title
  • Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia
  • Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia (en)
skos:prefLabel
  • Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia
  • Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia (en)
skos:notation
  • RIV/00064173:_____/08:00001288!RIV13-MZ0-00064173
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR9186), V
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 371198
http://linked.open...ai/riv/idVysledku
  • RIV/00064173:_____/08:00001288
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • yeast; protein; modifier; radiation; expression; phosphatase; mdm2; mutation; isoforms; functional assay (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [30DF25609CA6]
http://linked.open...i/riv/nazevZdroje
  • Leukemia Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 32
http://linked.open...iv/tvurceVysledku
  • Kozák, Tomáš
  • Špaček, Martin
http://linked.open...ain/vavai/riv/wos
  • 000254597400005
issn
  • 0145-2126
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.leukres.2007.06.022
is http://linked.open...avai/riv/vysledek of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 41 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software