About: N-3 polyunsaturated fatty acids in psychiatric diseases: Mechanisms and clinical data

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The lipids constitute majority of dry weight of mature human brain. From lipids, 35% is comprised of PUFA with long chain (LC-PUFA), especially docosahexaenoic acid (DHA) of n-3 family and arachidonic acid (AA) of n-6 family. Humans are dependent on dietary intake of both AA and DHA. Interestingly, the dietary n-6/n-3 ratio increased considerably during last century. LC-PUFAs play numerous roles in the brain, including structural (forming the physico-chemical properties in the lipid bilayer of cellular membranes) and signaling ones. Moreover, they influence neurogenesis and neurotransmission within the nervous tissue. The metabolites of PUFA modulate immune and inflammatory processes in the brain, oxidative stress as well as its consequences. Of high importance is also their connection with several metabolic factors involved in the proper function of the brain and/or were discovered to play a role in the pathogenesis of neuropsychiatric diseases – melatonin, homocysteine, leptin, and adiponectin. This review gives short view of the metabolism and possible mechanisms of PUFA n-3 action in the brain, and their role in the pathogenesis of psychiatric diseases. The lipids constitute majority of dry weight of mature human brain. From lipids, 35% is comprised of PUFA with long chain (LC-PUFA), especially docosahexaenoic acid (DHA) of n-3 family and arachidonic acid (AA) of n-6 family. Humans are dependent on dietary intake of both AA and DHA. Interestingly, the dietary n-6/n-3 ratio increased considerably during last century. LC-PUFAs play numerous roles in the brain, including structural (forming the physico-chemical properties in the lipid bilayer of cellular membranes) and signaling ones. Moreover, they influence neurogenesis and neurotransmission within the nervous tissue. The metabolites of PUFA modulate immune and inflammatory processes in the brain, oxidative stress as well as its consequences. Of high importance is also their connection with several metabolic factors involved in the proper function of the brain and/or were discovered to play a role in the pathogenesis of neuropsychiatric diseases – melatonin, homocysteine, leptin, and adiponectin. This review gives short view of the metabolism and possible mechanisms of PUFA n-3 action in the brain, and their role in the pathogenesis of psychiatric diseases. (en)
Title	N-3 polyunsaturated fatty acids in psychiatric diseases: Mechanisms and clinical data N-3 polyunsaturated fatty acids in psychiatric diseases: Mechanisms and clinical data (en)
skos:prefLabel	N-3 polyunsaturated fatty acids in psychiatric diseases: Mechanisms and clinical data N-3 polyunsaturated fatty acids in psychiatric diseases: Mechanisms and clinical data (en)
skos:notation	RIV/00064165:_____/12:12579!RIV13-MZ0-00064165
http://linked.open...avai/predkladatel	Všeobecná fakultní nemocnice v Praze
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NT13199), Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Zeman, Miroslav Jirák, Roman Raboch, Jiří Žák, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	155187
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/12:12579
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Docosahexaenoic acid; arachidonic acid; eicosanoids; docosanoids; depression; psychiatric disease (en)
http://linked.open.../riv/klicoveSlovo	Docosahexaenoic acid depression eicosanoids arachidonic acid docosanoids psychiatric disease
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[7748956BABA8]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Selected genetic and nutritional factors in pathogenesis of metabolic syndrome: importance of polyunsaturated fatty acids.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Jirák, Roman Raboch, Jiří Vecka, Marek Zeman, Miroslav Žák, Aleš
http://linked.open...n/vavai/riv/zamer	Neuropsychiatrické aspekty neurodegenerativních onemocnění
issn	0172-780X
number of pages	13 (xsd:int)
is http://linked.open...avai/riv/vysledek of	N-3 polyunsaturated fatty acids in psychiatric diseases: Mechanisms and clinical data

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