About: Clinical correlates of grey matter pathology in multiple sclerosis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1186/1471-2377-12-10
Description	Traditionally, multiple sclerosis has been viewed as a disease predominantly affecting white matter. However, this view has lately been subject to numerous changes, as new evidence of anatomical and histological changes as well as of molecular targets within the grey matter has arisen. This advance was driven mainly by novel imaging techniques, however, these have not yet been implemented in routine clinical practice. The changes in the grey matter are related to physical and cognitive disability seen in individuals with multiple sclerosis. Furthermore, damage to several grey matter structures can be associated with impairment of specific functions. Therefore, we conclude that grey matter damage - global and regional - has the potential to become a marker of disease activity, complementary to the currently used magnetic resonance markers ( global brain atrophy and T2 hyperintense lesions). Furthermore, it may improve the prediction of the future disease course and response to therapy in individual patients and may also become a reliable additional surrogate marker of treatment effect. Traditionally, multiple sclerosis has been viewed as a disease predominantly affecting white matter. However, this view has lately been subject to numerous changes, as new evidence of anatomical and histological changes as well as of molecular targets within the grey matter has arisen. This advance was driven mainly by novel imaging techniques, however, these have not yet been implemented in routine clinical practice. The changes in the grey matter are related to physical and cognitive disability seen in individuals with multiple sclerosis. Furthermore, damage to several grey matter structures can be associated with impairment of specific functions. Therefore, we conclude that grey matter damage - global and regional - has the potential to become a marker of disease activity, complementary to the currently used magnetic resonance markers ( global brain atrophy and T2 hyperintense lesions). Furthermore, it may improve the prediction of the future disease course and response to therapy in individual patients and may also become a reliable additional surrogate marker of treatment effect. (en)
Title	Clinical correlates of grey matter pathology in multiple sclerosis Clinical correlates of grey matter pathology in multiple sclerosis (en)
skos:prefLabel	Clinical correlates of grey matter pathology in multiple sclerosis Clinical correlates of grey matter pathology in multiple sclerosis (en)
skos:notation	RIV/00064165:_____/12:11529!RIV13-MZ0-00064165
http://linked.open...avai/predkladatel	Všeobecná fakultní nemocnice v Praze
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Horáková, Dana Blahová-Dušánková, Jana Kalinčík, Tomáš Doležal, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	127426
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/12:11529
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Relapsing-remitting ms; adaptive functional-changes; mild cognitive impairment; voxel-based morphometry; primary progressive ms; whole-brain atrophy; deep gray-matter; cortical-lesions; white-matter; volume changes (en)
http://linked.open.../riv/klicoveSlovo	volume changes voxel-based morphometry cortical-lesions mild cognitive impairment Relapsing-remitting ms adaptive functional-changes deep gray-matter primary progressive ms white-matter whole-brain atrophy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[125EECCE7738]
http://linked.open...i/riv/nazevZdroje	BMC Neurology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Horáková, Dana Doležal, Ondřej Blahová-Dušánková, Jana Kalinčík, Tomáš
http://linked.open...ain/vavai/riv/wos	000301950900001
http://linked.open...n/vavai/riv/zamer	Neuropsychiatrické aspekty neurodegenerativních onemocnění
issn	1471-2377
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Clinical correlates of grey matter pathology in multiple sclerosis

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