About: COMT polymorphisms in impulsively violent offenders with antisocial personality disorder

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	OBJECTIVE: The relationship between catechol-O-methyltransferase (COMT) polymorphisms and violent behaviour was tested in highly selected group of non-psychotic violent offenders. METHODS: We conducted an association study comparing 47 male repeatedly sentenced for impulsive violent attacks diagnosed with Antisocial Personality Disorder (APD) with 43 healthy male controls matched on education. Three COMT polymorphisms were analysed: COMT Val(158)Met and COMT Ala(146)Val on exon 4, and untranslated polymorphism on the 611, exon, at the regulatory region of the COMT gene with deletion-insertion character del/C. RESULTS: Logistic regression analysis revealed that while Val(158)Met is not associated with violence in APD, another COMT polymorphism - COMT Ala(146)Val is more frequent among violent offenders with APD (p=0.017). OBJECTIVE: The relationship between catechol-O-methyltransferase (COMT) polymorphisms and violent behaviour was tested in highly selected group of non-psychotic violent offenders. METHODS: We conducted an association study comparing 47 male repeatedly sentenced for impulsive violent attacks diagnosed with Antisocial Personality Disorder (APD) with 43 healthy male controls matched on education. Three COMT polymorphisms were analysed: COMT Val(158)Met and COMT Ala(146)Val on exon 4, and untranslated polymorphism on the 611, exon, at the regulatory region of the COMT gene with deletion-insertion character del/C. RESULTS: Logistic regression analysis revealed that while Val(158)Met is not associated with violence in APD, another COMT polymorphism - COMT Ala(146)Val is more frequent among violent offenders with APD (p=0.017). (en)
Title	COMT polymorphisms in impulsively violent offenders with antisocial personality disorder COMT polymorphisms in impulsively violent offenders with antisocial personality disorder (en)
skos:prefLabel	COMT polymorphisms in impulsively violent offenders with antisocial personality disorder COMT polymorphisms in impulsively violent offenders with antisocial personality disorder (en)
skos:notation	RIV/00064165:_____/09:4632!RIV10-MZ0-00064165
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GA206/07/0779), V, Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Papežová, Hana Žukov, Ilja Raboch, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	307995
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/09:4632
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	COMT; Val 158Met polymorphism; antisocial personality disorder; impulsivity; aggressive behavior; dopamine (en)
http://linked.open.../riv/klicoveSlovo	aggressive behavior antisocial personality disorder dopamine COMT impulsivity Val 158Met polymorphism
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[478201CF9E2F]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Social modulation: genetic variation in the social life of mice
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Raboch, Jiří Stopka, Pavel Vevera, Jan Papežová, Hana Žukov, Ilja Stopková, Romana Albrecht, Tomas Bes, Mireia
http://linked.open...ain/vavai/riv/wos	000275266400013
http://linked.open...n/vavai/riv/zamer	Ekologické procesy v evoluci modelových skupin organismů
issn	0172-780X
number of pages	4 (xsd:int)
is http://linked.open...avai/riv/vysledek of	COMT polymorphisms in impulsively violent offenders with antisocial personality disorder COMT polymorphisms in impulsively violent offenders with antisocial personality disorder COMT polymorphisms in impulsively violent offenders with antisocial personality disorder COMT polymorphisms in impulsively violent offenders with antisocial personality disorder

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