About: Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Neurochemical approaches to antidepressant effects and depressive disorder are focusing on G-protein coupled receptors (GPCR) and subsequent signalling. We studied the effect of acute administration of fluoxetine or NECA agonist of adenosine receptor on C6 glioma cells and natural killer (NK) cell line. ELISA was used for detection of the main types of G-protein alpha subunits from isolated membranes of tested cells. Significant reduction of G alpha q/11 subunits after administration of fluoxetine or NECA was found. In contrast, no significant impact on G alpha s or G alpha i1,2 subunit levels of C6 glioma cells were observed. Lowered Gq/11 signalling was in accordance with decreased 2(nd) messenger 1,4,5 IP3 formation by PLC. Acute effect of fluoxetine or NECA agonist on NK cell line resulted in significantly reduced G alpha q/11 levels without changes in G alpha s and G alpha i1,2. Furthermore, we determined that NECA was able to abolish fluoxetine-evoked G alpha q/11 levels of NK cell line. Neurochemical approaches to antidepressant effects and depressive disorder are focusing on G-protein coupled receptors (GPCR) and subsequent signalling. We studied the effect of acute administration of fluoxetine or NECA agonist of adenosine receptor on C6 glioma cells and natural killer (NK) cell line. ELISA was used for detection of the main types of G-protein alpha subunits from isolated membranes of tested cells. Significant reduction of G alpha q/11 subunits after administration of fluoxetine or NECA was found. In contrast, no significant impact on G alpha s or G alpha i1,2 subunit levels of C6 glioma cells were observed. Lowered Gq/11 signalling was in accordance with decreased 2(nd) messenger 1,4,5 IP3 formation by PLC. Acute effect of fluoxetine or NECA agonist on NK cell line resulted in significantly reduced G alpha q/11 levels without changes in G alpha s and G alpha i1,2. Furthermore, we determined that NECA was able to abolish fluoxetine-evoked G alpha q/11 levels of NK cell line. (en)
Title	Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes (en)
skos:prefLabel	Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes (en)
skos:notation	RIV/00027162:_____/11:#0000824!RIV12-MZE-00027162
http://linked.open...avai/predkladatel	Výzkumný ústav veterinárního lékařství, v.v.i,
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED0006/01/01), P(IAA601680801), Z(MSM0021620849), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Ondráčková, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	196274
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/11:#0000824
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	C6 glioma cells; NK cells; 1,4,5 IP3; fluoxetine; astrocyte; trimeric GTP binding protein; G-protein; GPCR; NECA agonist; adenosine receptor; G alpha q/11 signalling; interleukin 2; neuroimmunomodulation (en)
http://linked.open.../riv/klicoveSlovo	NK cells 1 G-protein 4 5 IP3 C6 glioma cells G alpha q/11 signalling GPCR NECA agonist adenosine receptor astrocyte fluoxetine interleukin 2 neuroimmunomodulation trimeric GTP binding protein
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[E6B6F1DC8D3F]
http://linked.open...i/riv/nazevZdroje	NEUROENDOCRINOLOGY LETTERS
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Advanced Microbiology & Immunology Research in Veterinary Medicine Modulation of immunocyte subpopulations by transmitter systems during development of defense mechanisms
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Lisá, V. Fišerová, A. Kovářů, F. Kovářů, H. Ondráčková, Petra
http://linked.open...ain/vavai/riv/wos	000294089700010
http://linked.open...n/vavai/riv/zamer	Neuropsychiatrické aspekty neurodegenerativních onemocnění Animal disease research, prevention and food chain protection
issn	0172-780X
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes

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