About: Experimental infection of weaned piglets with enterotoxigenic Escherichia coli O149:F4

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Enterotoxigenic Escherichia coli is an important enteric pathogen causing post-weaning diarrhoea in piglets. Enterotoxins of E. coli induce the release of fluid into the intestines without apparent inflammation. Some serotypes of E. coli, especially O149:F4 can often be identified in association with haemorrhagic gastroenteritis. In this study we infected the weaned piglets (n = 53) by oral administration of enterotoxigenic E. coli O149:F4 strains isolated from piglets suffering from haemorrhagic gastroenteritis. The clinical course of infection and shedding of the challenge E. coli strain in the faeces of infected piglets was monitored for 14 days. The challenge strain soon outnumbered the other E. coli types in the intestines of most piglets. Diarrhoea developed in the majority of piglets and its severity varied. Severe diarrhoea was observed in 10% of the piglets but only one piglet died due to dehydration. No inflammatory lesions were detected in the intestines of the dead piglet and the other euthanized piglets. We assume that development of haemorrhagic gastroenteritis depends on the involvement of other factors that need to be identified. E. coli O149:F4 are only one of the causative factors of haemorrhagic gastroenteritis in piglets after weaning. Enterotoxigenic Escherichia coli is an important enteric pathogen causing post-weaning diarrhoea in piglets. Enterotoxins of E. coli induce the release of fluid into the intestines without apparent inflammation. Some serotypes of E. coli, especially O149:F4 can often be identified in association with haemorrhagic gastroenteritis. In this study we infected the weaned piglets (n = 53) by oral administration of enterotoxigenic E. coli O149:F4 strains isolated from piglets suffering from haemorrhagic gastroenteritis. The clinical course of infection and shedding of the challenge E. coli strain in the faeces of infected piglets was monitored for 14 days. The challenge strain soon outnumbered the other E. coli types in the intestines of most piglets. Diarrhoea developed in the majority of piglets and its severity varied. Severe diarrhoea was observed in 10% of the piglets but only one piglet died due to dehydration. No inflammatory lesions were detected in the intestines of the dead piglet and the other euthanized piglets. We assume that development of haemorrhagic gastroenteritis depends on the involvement of other factors that need to be identified. E. coli O149:F4 are only one of the causative factors of haemorrhagic gastroenteritis in piglets after weaning. (en)
Title	Experimental infection of weaned piglets with enterotoxigenic Escherichia coli O149:F4 Experimental infection of weaned piglets with enterotoxigenic Escherichia coli O149:F4 (en)
skos:prefLabel	Experimental infection of weaned piglets with enterotoxigenic Escherichia coli O149:F4 Experimental infection of weaned piglets with enterotoxigenic Escherichia coli O149:F4 (en)
skos:notation	RIV/00027162:_____/11:#0000739!RIV12-MZE-00027162
http://linked.open...avai/predkladatel	Výzkumný ústav veterinárního lékařství, v.v.i,
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1B44020), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Alexa, Pavel Konstantinová, Lucie Šrámková-Zajacová, Zuzana Hamřík, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	198767
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/11:#0000739
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	haemorrhagic gastroenteritis; K88, diarrhoea; enterotoxins (en)
http://linked.open.../riv/klicoveSlovo	K88 diarrhoea enterotoxins haemorrhagic gastroenteritis
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[9F5CD51E16AB]
http://linked.open...i/riv/nazevZdroje	Acta Veterinaria Brno
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The pathogenesis of enteric colibacillosis and salmonellosis of pigs.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	80
http://linked.open...iv/tvurceVysledku	Alexa, Pavel Hamřík, Jaroslav Konstantinová, Lucie Šrámková-Zajacová, Zuzana
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0001-7213
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.2754/avb201180040337
is http://linked.open...avai/riv/vysledek of	Experimental infection of weaned piglets with enterotoxigenic Escherichia coli O149:F4 Experimental infection of weaned piglets with enterotoxigenic Escherichia coli O149:F4

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